ArticlePLoS neglected tropical diseases2021
Sodium channel activation underlies transfluthrin repellency in Aedes aegypti.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Repellent effects of insecticides against Aedes aegypti: a systematic review.Parasites & vectors · 2025Pooled it
- Commercial permethrin elicits chemoreceptive responses on different Anopheles gambiae sensory appendages.Pest management science · 2026Article
- Do natural or synthetic excito-repellents work better? A study on coastal malaria vectorPeerJ · 2026Article
- Molecular markers of reduced behavioral sensitivity to transfluthrin in Anopheles gambiae s.s. from Western Kenya.BMC genomics · 2025Article
- Repellency and toxicity of long-lasting insecticide-treated bed nets (LLINs) to bed bugs.PloS one · 2025Article
- The BiteBarrier perimeter: A passive spatial device for tick control and bite prevention.Current research in parasitology & vector-borne diseases · 2025Article
- Article
- Repellency of N,N-diethyl-3-methylbenzamide (DEET) during host-seeking behavior of bed bugs (Hemiptera: Cimicidae) in binary choice olfactometer assays.Journal of medical entomology · 2024Article
- Non-contact detection of pyrethroids widely used in vector control by Anopheles mosquitoes.PloS one · 2024Article
- Insecticidal and Repellent Properties of Rapid-Acting Fluorine-Containing Compounds againstACS infectious diseases · 2023Article
- Comprehensive Molecular Interaction Studies to Construe the Repellent/Kill Activity of Geraniol During Binding Event Against Aedes aegypti Proteins.Molecular biotechnology · 2023Article
- Methanolic Extracts ofPlants (Basel, Switzerland) · 2022Article
- Bioallethrin activates specific olfactory sensory neurons and elicits spatial repellency in Aedes aegypti.Pest management science · 2022Article
- Article
- Review
- Vapor phase repellency and insecticidal activity of pyridinyl amides against anopheline mosquitoes.Current research in parasitology & vector-borne diseases · 2021Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundVolatile pyrethroid insecticides, such as transfluthrin, have received increasing attention for their potent repellent activities in recent years for controlling human disease vectors. It has been long understood that pyrethroids kill insects by promoting activation and inhibiting inactivation of voltage-gated sodium channels. However, the mechanism of pyrethroid repellency remains poorly understood and controversial. METHODOLOGY/PRINCIPAL
findingsHere, we show that transfluthrin repels Aedes aegypti in a hand-in-cage assay at nonlethal concentrations as low as 1 ppm. Contrary to a previous report, transfluthrin does not elicit any electroantennogram (EAG) responses, indicating that it does not activate olfactory receptor neurons (ORNs). The 1S-cis isomer of transfluthrin, which does not activate sodium channels, does not elicit repellency. Mutations in the sodium channel gene that reduce the potency of transfluthrin on sodium channels decrease transfluthrin repellency but do not affect repellency by DEET. Furthermore, transfluthrin enhances DEET repellency. CONCLUSIONS/SIGNIFICANCE: These results provide a surprising example that sodium channel activation alone is sufficient to potently repel mosquitoes. Our findings of sodium channel activation as the principal mechanism of transfluthrin repellency and potentiation of DEET repellency have broad implications in future development of a new generation of dual-target repellent formulations to more effectively repel a variety of human disease vectors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.