Evidence map›Paper›PMID 34236619›Full record

ArticleNeurocritical care2021

Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.

Jan Claassen, Yama Akbari, Sheila Alexander, Mary Kay Bader, Kathleen Bell, Thomas P Bleck, Melanie Boly, Jeremy Brown, Sherry H-Y Chou, Michael N Diringer and 44 more

Abstract read
In one paragraph

Article in Neurocritical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Outcomes in Traumatic Brain Injury: Can Electroencephalography Predict the Unpredictable?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Disorders of Consciousness: Classification and Taxonomy.Physical medicine and rehabilitation clinics of North America · 2024
    Review
  14. Covert consciousness.NeuroRehabilitation · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors.

Jan ClaassenDepartment of Neurology, Columbia University and New York-Presbyterian Hospital, 177 Fort Washington Avenue, MHB 8 Center, Room 300, New York City, NY, 10032, USA. jc1439@columbia.edu.ORCID http://orcid.org/0000-0002-5893-8531
Yama AkbariDepartments of Neurology, Neurological Surgery, and Anatomy & Neurobiology and Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, USA.
Sheila AlexanderAcute and Tertiary Care, School of Nursing and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Mary Kay BaderMission Hospital, Mission Viejo, CA, USA.
Kathleen BellDepartment of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Thomas P BleckDavee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Melanie BolyDepartment of Neurology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Jeremy BrownOffice of Emergency Care Research, Division of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Sherry H-Y ChouDepartments of Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Michael N DiringerDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
Brian L EdlowDepartment of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital and Harvard Medical School, Harvard University, Boston, MA, USA.
Brandon ForemanDepartments of Neurology and Rehabilitation Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Joseph T GiacinoDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Harvard University, Boston, MA, USA.
Olivia GosseriesGIGA Consciousness After Coma Science Group, University of Liege, Liege, Belgium.
Theresa GreenSchool of Nursing, Queensland University of Technology, Kelvin Grove, QLD, Australia.
David M GreerDepartment of Neurology, School of Medicine, Boston University, Boston, MA, USA.
Daniel F HanleyDivision of Brain Injury Outcomes, Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jed A HartingsDepartment of Neurosurgery, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Raimund HelbokNeurocritical Care Unit, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
J Claude HemphillDepartment of Neurology, Weill Institute for Neurosciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
H E HinsonDepartment of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
Karen HirschDepartment of Neurology, Stanford University, Palo Alto, CA, USA.
Theresa HumanDepartment of Pharmacy, Barnes Jewish Hospital, St. Louis, MO, USA.
Michael L JamesDepartments of Anesthesiology and Neurology, Duke University, Durham, NC, USA.
Nerissa KoDepartment of Neurology, Weill Institute for Neurosciences, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Daniel KondziellaDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Sarah LivesayCollege of Nursing, Rush University, Chicago, IL, USA.
Lori K MaddenCenter for Nursing Science, University of California, Davis, Sacramento, CA, USA.
Shraddha MainaliDepartment of Neurology, The Ohio State University, Columbus, OH, USA.
Stephan A MayerDepartment of Neurology, New York Medical College, Valhalla, NY, USA.
Victoria McCredieInterdepartmental Division of Critical Care, Department of Respirology, University of Toronto, Toronto, ON, Canada.
Molly M McNettCollege of Nursing, The Ohio State University, Columbus, OH, USA.
Geert MeyfroidtDepartment of Intensive Care Medicine, University Hospitals Leuven and University of Leuven, Leuven, Belgium.
Martin M MontiDepartments of Neurosurgery and Psychology, Brain Injury Research Center, University of California, Los Angeles, Los Angeles, CA, USA.
Susanne MuehlschlegelDepartments of Neurology, Anesthesiology/Critical Care, and Surgery, Medical School, University of Massachusetts, Worcester, MA, USA.
Santosh MurthyDepartment of Neurology, Weill Cornell Medical College, New York City, NY, USA.
Paul NyquistDivision of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
DaiWai M OlsonDepartments of Neurology and Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Javier ProvencioDepartments of Neurology and Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Eric RosenthalDepartment of Neurology, Harvard Medical School, Harvard University, Boston, MA, USA.
Gisele Sampaio SilvaDepartment of Neurology, Albert Einstein Israelite Hospital and Universidade Federal de São Paulo, São Paulo, Brazil.
Simone SarassoDepartment of Biomedical and Clinical Sciences "L. Sacco", Università degli Studi di Milano, Milan, Italy.
Nicholas D SchiffDepartment of Neurology and Brain Mind Research Institute, Weill Cornell Medicine, Cornell University, New York City, NY, USA.
Tarek SharsharDepartment of Intensive Care, Paris Descartes University, Paris, France.
Lori ShutterDepartments of Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Robert D StevensDivision of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Paul VespaDepartments of Neurosurgery and Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Walter VidettaNational Hospital Alejandro Posadas, Buenos Aires, Argentina.
Amy WagnerDepartment of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Wendy ZiaiDivision of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
John WhyteMoss Rehabilitation Research Institute, Elkins Park, PA, USA.
Elizabeth ZinkDivision of Neurosciences Critical Care, Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jose I SuarezDivision of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Curing Coma Campaign

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
RECONFIG - REcovery of CONsciousness Following Intracerebral hemorrhaGeR01NS106014 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2023
$3.6M
MicroRNA Endotypes of Systemic Inflammation in Sub-Arachnoid hemorrhaGE (MESSAGE)R21NS113037 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHOU, SHERRY HSIANG-YI · 2019 to 2019
$390k
BAsIC - Brain-computer-interface practical Application in the Intensive Care unit: a pilot studyR03NS112760 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2020
$162k
NCATS NIH HHS UL1 TR001863NINDS NIH HHS R01 NS106014NINDS NIH HHS R03 NS112760NINDS NIH HHS R21 NS113037
6 · The paper itself

Abstract

Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.

Indexed as

ComaConsciousnessBiomarkersCongresses as TopicConsciousness DisordersHumansNational Institutes of Health (U.S.)United StatesBiomarkersBiomarkersComaConsciousnessElectrophysiologyMagnetic resonance imaging

Identifiers

PMID34236619
PMCPMC8264966

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.