Evidence map›Paper›PMID 34236572›Full record

ArticleLa Radiologia medica2021

Magnetic resonance imaging (MRI) radiomics of papillary thyroid cancer (PTC): a comparison of predictive performance of multiple classifiers modeling to identify cervical lymph node metastases before surgery.

Hui Qin, Qiao Que, Peng Lin, Xin Li, Xin-Rong Wang, Yun He, Jun-Qiang Chen, Hong Yang

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in La Radiologia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  7. Predicting lymph node metastasis in papillary thyroid carcinoma: radiomics using two types of ultrasound elastography.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
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  15. Radiomics in colorectal cancer patients.World journal of gastroenterology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hui Qin *Department of Medical Ultrasonics, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Guangxi Zhuang Autonomous Region, Nanning, People's Republic of China.
Qiao Que *Department of Medical Ultrasonics, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Guangxi Zhuang Autonomous Region, Nanning, People's Republic of China.
Peng LinDepartment of Medical Ultrasonics, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Guangxi Zhuang Autonomous Region, Nanning, People's Republic of China.
Xin LiDepartment of GE Healthcare Global Research, GE Healthcare, Shanghai, 201203, People's Republic of China.
Xin-Rong WangDepartment of GE Healthcare Global Research, GE Healthcare, Shanghai, 201203, People's Republic of China.
Yun HeDepartment of Medical Ultrasonics, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Guangxi Zhuang Autonomous Region, Nanning, People's Republic of China.
Jun-Qiang ChenDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Guangxi Zhuang Autonomous Region, Nanning, People's Republic of China. gxmufh@163.com.
Hong YangDepartment of Medical Ultrasonics, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Guangxi Zhuang Autonomous Region, Nanning, People's Republic of China. yanghong@gxmu.edu.cn.
First Affiliated Hospital of GuangXi Medical University · CNGuangxi Medical University · CNUnited Imaging Healthcare (China) · CN

Funding

Guangxi National Nature Science Foundation 2017GXNSFAA198253Guangxi Science and Technology Program GuiKeAB17195020Guangxi Scientific Research and Technology Development Plan 1598011-4National Natural Science Foundation of China NSFC81860319National Natural Science Foundation of China NSFC81960329
6 · The paper itself

Abstract

purposeTo compare predictive efficiency of multiple classifiers modeling and establish a combined magnetic resonance imaging (MRI) radiomics model for identifying lymph node (LN) metastases of papillary thyroid cancer (PTC) preoperatively. MATERIALS AND

methodsA retrospective analysis based on the preoperative MRI scans of 109 PTC patients including 77 patients with LN metastases and 32 patients without metastases was conducted, and we divided enroll cases into trained group and validation group. Radiomics signatures were selected from fat-suppressed T2-weighted MRI images, and the optimal characteristics were confirmed by spearman correlation test, hypothesis testing and random forest methods, and then, eight predictive models were constructed by eight classifiers. The receiver operating characteristic (ROC) curves analysis were performed to demonstrate the effectiveness of the models.

resultsThe area under the curve (AUC) of ROC based on MRI texture diagnosed LN status by naked eye was 0.739 (sensitivity = 0.571, specificity = 0.906). Based on the 5 optimal signatures, the best AUC of MRI radiomics model by logistics regression classifier had a considerable prediction performance with AUCs 0.805 in trained group and 0.760 in validation group, respectively, and a combination of best radiomics model with visual diagnosis of MRI texture had a high AUC as 0.969 (sensitivity = 0.938, specificity = 1.000), suggesting combined model had a preferable diagnostic efficiency in evaluating LN metastases of PTC.

conclusionOur combined radiomics model with visual diagnosis could be a potentially effective strategy to preoperatively predict LN metastases in PTC patients before clinical intervention.

Indexed as

AdultDecision TreesFemaleHumansLogistic ModelsLymphatic MetastasisMagnetic Resonance ImagingMaleModels, StatisticalNeckPreoperative CareRetrospective StudiesROC CurveSensitivity and SpecificityStatistics, NonparametricThyroid Cancer, PapillaryCervical lymph node metastasesMagnetic resonance imagingPapillary thyroid cancer

Identifiers

PMID34236572
OpenAlexW3177649181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.