ReviewCurrent rheumatology reports2021
Re-Examining Myofascial Pain Syndrome: Toward Biomarker Development and Mechanism-Based Diagnostic Criteria.
Review in Current rheumatology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06060925 (Multimodal Imaging Biomarkers for Investigating Fascia, Muscle and Vasculature in Myofascial Pain), which is not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Imaging Biomarkers for Investigating Fascia, Muscle and Vasculature in Myofascial Pain
Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Comparative effects of Bowen therapy and tennis ball technique on pain and functional disability in patients with thoracic myofascial pain syndrome.Journal of orthopaedic surgery and research · 2023Trial
- The DC/TMD Conundrum.Clinical oral investigations · 2026Review
- Adapting Tension-Type Headache to the International Association for the Study of Pain (IASP) Taxonomy: A Conceptual Proposal.Biomedicines · 2026Review
- Validity, Reliability, and Responsiveness of a New Device for Measuring Pressure Pain Thresholds.Journal of clinical medicine · 2026Article
- Immediate Effects of Dry Needling in Patients with Myofascial Temporomandibular Disorders: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2026Article
- Myofascial pain in older adults: a geroscience-informed framework integrating precision geriatrics and digital therapeutics.Frontiers in aging neuroscience · 2026Review
- A Time-Efficient and Reproducible Rat Model of Myofascial Pain Syndrome-Like Phenotypes Induced by Repeated Mechanical Impact and Eccentric Exercise.Journal of pain research · 2026Article
- Cooled Radiofrequency at Five Revised Targets for Short-Term Pain and Physical Performance Improvement in Elderly Patients with Knee Osteoarthritis: A Prospective Four-Case Reports.Geriatrics (Basel, Switzerland) · 2025Article
- Ultrasound-guided platelet-rich plasma injection improves pain, function and symmetry in lumbar myofascial pain syndrome: A case report.World journal of clinical cases · 2025Article
- Ultrasound-guided injection of platelet-rich plasma alleviated pain and improved function for individuals with myofascial pain syndrome: a retrospective case series study.BMC musculoskeletal disorders · 2025Article
- Ultrasound features of myofascial trigger points: a multimodal study integrating preliminary histological findings from the upper trapezius.Scientific reports · 2025Article
- Prevalence of Myofascial Trigger Points in Patients with Radiating and Non-Radiating Low Back Pain: A Systematic Review.Biomedicines · 2025Review
- The Rainbow and the Umbrella of Temporomandibular Disorders-Total Antioxidant Capacity and Total Oxidant Status in Patients with Myofascial Pain with Referral.Journal of clinical medicine · 2025Article
- Myofascial Pain Syndrome: An Update on Clinical Characteristics, Etiopathogenesis, Diagnosis, and Treatment.Muscle & nerve · 2025Review
- Intratissue percutaneous electrolysis and deep dry needling compared to a standard physiotherapy protocol in the treatment of whiplash syndrome: study protocol for a randomized controlled trial.Frontiers in rehabilitation sciences · 2025Article
- Characteristics of patients with myofascial pain syndrome of the low back.Scientific reports · 2024Article
- Advancing musculoskeletal diagnosis and therapy: a comprehensive review of trigger point theory and muscle pain patterns.Frontiers in medicine · 2024Article
- Identification of Myofascial Trigger Point Using the Combination of Texture Analysis in B-Mode Ultrasound with Machine Learning Classifiers.Sensors (Basel, Switzerland) · 2023Article
- Preclinical efficacy of TZG in myofascial pain syndrome by impairing PI3K-RAC2 signaling-mediated neutrophil extracellular traps.iScience · 2023Article
- Comparative Techniques of Acupuncture and Dry Needling Intersecting with Trigger Point Physiology and Diagnostics: A Cross-Discipline Narrative Review.Medical acupuncture · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewWe discuss the need for a mechanism-based diagnostic framework with a focus on the development of objective measures (e.g., biomarkers) that can potentially be added to the diagnostic criteria of the syndrome. Potential biomarkers are discussed in relation to current knowledge on the pathophysiology of myofascial pain syndrome (MPS), including alterations in redox status, inflammation, and the myofascial trigger point (MTrP) biochemical milieu, as well as imaging and neurophysiological outcomes. Finally, we discuss the long-term goal of conducting a Delphi survey, to assess the influence of putative MPS biomarkers on clinician opinion, in order to ultimately develop new criteria for the diagnosis of MPS. RECENT
findingsMyofascial pain syndrome (MPS) is a prevalent healthcare condition associated with muscle weakness, impaired mood, and reduced quality of life. MPS is characterized by the presence of myofascial trigger points (MTrPs): stiff and discrete nodules located within taut bands of skeletal muscle that are painful upon palpation. However, physical examination of MTrPs often yields inconsistent results, and there is no gold standard by which to diagnose MPS. The current MPS diagnostic paradigm has an inherent subjectivity and the absence of correlation with the underlying pathophysiology. Recent advancements in ultrasound imaging, systemic biomarkers, MTrP-specific biomarkers, and the assessment of dysfunction in the somatosensorial system may all contribute to improved diagnostic effectiveness of MPS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.