Evidence map›Paper›PMID 34236473›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2021

Ocular perfusion in patients with reduced left ventricular ejection fraction measured by optical coherence tomography angiography.

Maged Alnawaiseh, Franziska Eckardt, Natasa Mihailovic, Gerrit Frommeyer, Raphael Diener, Friederike Rosenberger, Lars Eckardt, Nicole Eter, Larissa Lahme, Philipp Sebastian Lange

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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maged Alnawaiseh *Department of Ophthalmology, Klinikum Fulda gAG, Hospital Fulda, University of Marburg, Campus Fulda, Fulda, Germany. Maged.Alnawaiseh@klinikum-fulda.de.
Franziska Eckardt *Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.
Natasa MihailovicDepartment of Ophthalmology, Klinikum Fulda gAG, Hospital Fulda, University of Marburg, Campus Fulda, Fulda, Germany.
Gerrit FrommeyerDivision of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
Raphael DienerDepartment of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.
Friederike RosenbergerDepartment of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.
Lars EckardtDivision of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
Nicole EterDepartment of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.
Larissa Lahme *Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.
Philipp Sebastian Lange *Division of Electrophysiology, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aim of this study is to evaluate retinal and optic nerve head (ONH) perfusion in patients with systolic chronic heart failure (CHF) compared to healthy control subjects.

methodsTwenty-seven eyes of 27 patients with CHF (study group) and 31 eyes of 31 healthy subjects (control group) were prospectively included in this study. CHF Patients had a left ventricular ejection fraction (LVEF) < 50% and were classified by New York Heart Association (NYHA) class. OCT-A was performed using RTVue XR Avanti with AngioVue (Optovue, Inc, Fremont, CA, USA). The area of the foveal avascular zone (FAZ) and flow density (FD) data were extracted and analyzed.

resultsThere was no significant difference in the signal strength index between the study group (group 1) and the control group (group 2) (ONH: p = 0.015; macula: p = 0.703). The difference in the area of the foveal avascular zone between the two groups was also not significant (p = 0.726). The flow density (whole en face) in the ONH (RPC) in group 1 was significantly lower compared to control (group 1 = 48.40 ± 2.48 (49.0 [46.7, 50.3]); group 2 = 50.15 ± 1.85 (50.6 [48.5, 51.70]); p = 0.008). There was a significant and strong correlation between LVEF and the macular flow density (whole en face) (superficial: rs = 0.605 deep: rs = 0.425, p < 0.01).

conclusionsPatients with CHF showed reduced flow density compared with healthy controls. The reduced FD correlated with the LVEF and the functional (NYHA) class. Retinal perfusion as measured using OCTA might provide an insight into the global microperfusion and hemodynamic state of heart failure patients.

Indexed as

Retinal VesselsTomography, Optical CoherenceFluorescein AngiographyHumansPerfusionStroke VolumeVentricular Function, LeftCardiovascular diseasesHeart failureOptical coherence tomography angiographyOptic nerve and macular perfusionReduced left ventricular ejection fraction

Identifiers

PMID34236473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.