Evidence map›Paper›PMID 34236312›Full record

ArticleeLife2021

Pupal behavior emerges from unstructured muscle activity in response to neuromodulation in

Amicia D Elliott, Adama Berndt, Matthew Houpert, Snehashis Roy, Robert L Scott, Carson C Chow, Hari Shroff, Benjamin H White

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Amicia D ElliottNational Institute of Mental Health, National Institutes of Health, Bethesda, United States.ORCID 0000-0002-3089-1786
Adama BerndtNational Institute of Mental Health, National Institutes of Health, Bethesda, United States.
Matthew HoupertNational Institute of Mental Health, National Institutes of Health, Bethesda, United States.
Snehashis RoyNational Institute of Mental Health, National Institutes of Health, Bethesda, United States.
Robert L ScottNational Institute of Mental Health, National Institutes of Health, Bethesda, United States.
Carson C ChowNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, United States.ORCID 0000-0003-1463-9553
Hari ShroffNational Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, United States.
Benjamin H WhiteNational Institute of Mental Health, National Institutes of Health, Bethesda, United States.ORCID 0000-0003-0612-8075
National Institutes of Health · US

Funding

Identifying Neural Substrates of Behavior in Drosophila MelanogasterZIAMH002800 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI WHITE, BENJAMIN H · 2009 to 2025
$29.2M
Systems Neuroscience Imaging ResourceZICMH002963 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI USDIN, THEODORE · 2017 to 2025
$18.0M
Section on High Resolution Optical ImagingZIAEB000074 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI SHROFF, HARI · 2010 to 2022
$15.2M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI KEVIN R COOK, THOMAS KAUFMAN · 2014 to 2026
$13.5M
Correlations, fluctuations and variability in neural networksZIADK013024 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CHOW, CARSON · 2009 to 2025
$4.6M
Recording and Modeling Brain-wide Neuronal Activity of the Drosophila Pupal Ecdysis SequenceFI2GM117582 · NIGMS · U.S. NATIONAL INSTITUTE OF MENTAL HEALTH · PI ELLIOTT, AMICIA DEVIN · 2016 to 2016
–
Intramural NIH HHS ZIA MH002800Intramural NIH HHS ZIC MH002963NIGMS NIH HHS FI2 GM117582NIH HHS P40 OD018537
6 · The paper itself

Abstract

Identifying neural substrates of behavior requires defining actions in terms that map onto brain activity. Brain and muscle activity naturally correlate via the output of motor neurons, but apart from simple movements it has been difficult to define behavior in terms of muscle contractions. By mapping the musculature of the pupal fruit fly and comprehensively imaging muscle activation at single-cell resolution, we here describe a multiphasic behavioral sequence in

Indexed as

AnimalsBehavior, AnimalBrainComputational BiologyDrosophilaDrosophila melanogasterInvertebrate HormonesLarvaMoltingMotor NeuronsMusclesPupaReceptors, Peptidebursiconecdysis-triggering hormone receptor, DrosophilaInvertebrate HormonesReceptors, PeptidebursiconCCAPcomputational ethologyecdysisecdysis triggering hormoneneural circuitneuroscience

Identifiers

PMID34236312
PMCPMC8331185
OpenAlexW3180112923

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.