Evidence map›Paper›PMID 34236286›Full record

ArticlePharmaceutical biology2021

Maculosin, a non-toxic antioxidant compound isolated from

Babita Paudel, Rukusha Maharjan, Prajwal Rajbhandari, Niraj Aryal, Saefuddin Aziz, Keshab Bhattarai, Bikash Baral, Rajani Malla, Hari Datta Bhattarai

Abstract read
In one paragraph

Article in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  8. Cyclo(l-Pro-l-Tyr) Isolated from the Human Skin CommensalInternational journal of molecular sciences · 2024
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  9. Metabolic Comparison and Molecular Networking of Antimicrobials inInternational journal of molecular sciences · 2024
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  17. Recent Advances inJournal of fungi (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Babita PaudelCentral Department of Biotechnology, Tribhuvan University, Kirtipur, Nepal.
Rukusha MaharjanDepartment of Applied Microbiology and Food Technology, Research Institute for Bioscience and Biotechnology (RIBB), Kathmandu, Nepal.
Prajwal RajbhandariDepartment of Applied Microbiology and Food Technology, Research Institute for Bioscience and Biotechnology (RIBB), Kathmandu, Nepal.ORCID https://orcid.org/0000-0003-3159-8263
Niraj AryalDepartment of Pharmaceutical Biology, Eberhard Karls University, Tübingen, Germany.
Saefuddin AzizDepartment of Pharmaceutical Biology, Eberhard Karls University, Tübingen, Germany.
Keshab BhattaraiDepartment of Pharmaceutical Biology, Eberhard Karls University, Tübingen, Germany.
Bikash BaralDepartment of Biochemistry, University of Turku, Turku, Finland.
Rajani MallaCentral Department of Biotechnology, Tribhuvan University, Kirtipur, Nepal.
Hari Datta BhattaraiDepartment of Pharmaceutical Biology, Eberhard Karls University, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

context

objectiveThis study sought to isolate and characterize antioxidant molecules biosynthesized by MATERIALS AND

methodsThe compound was purified using bioassay-guided chromatography techniques. Nuclear magnetic resonance (NMR) experiments were carried out for structure elucidation. The antioxidant potential of the isolated compound was determined using DPPH free radical scavenging assay. The toxicity of the isolated compound was measured using a brine shrimp lethality (BSL) assay.

resultsEthyl acetate extract of

conclusionsMaculosin may be a leading drug candidate in various cosmetic and therapeutic applications owing to its strong antioxidant and non-toxic properties.

Indexed as

AnimalsAntioxidantsArtemiaBiphenyl CompoundsFree Radical ScavengersInhibitory Concentration 50Magnetic Resonance SpectroscopyPeptides, CyclicPicratesPiperazinesSecondary MetabolismStreptomycesToxicity Tests1,1-diphenyl-2-picrylhydrazylAntioxidantsBiphenyl CompoundsFree Radical ScavengersmaculosinPeptides, CyclicPicratesPiperazinesBioactivitybrine shrimp toxicitychromatographydiketopiperazineDPPH free radicalnatural products

Identifiers

PMID34236286
PMCPMC8274501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.