Evidence map›Paper›PMID 34236178›Full record

ArticleEnvironmental science & technology2021

Impact of an Urban Sanitation Intervention on Enteric Pathogen Detection in Soils.

Drew Capone, David Berendes, Oliver Cumming, David Holcomb, Jackie Knee, Konstantinos T Konstantinidis, Karen Levy, Rassul Nalá, Benjamin B Risk, Jill Stewart and 1 more

Abstract read
In one paragraph

Article in Environmental science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  17. Producing ratio measures of effect with quantitative microbial risk assessment.Risk analysis : an official publication of the Society for Risk Analysis · 2023
    Article
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  20. PersistentEnvironmental science & technology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Drew CaponeDepartment of Environmental Sciences and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States of America.ORCID 0000-0002-2138-6382
David BerendesWaterborne Disease Prevention Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, United States of America.
Oliver CummingDepartment of Disease Control, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom.
David HolcombDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States of America.ORCID 0000-0003-4055-7164
Jackie KneeDepartment of Disease Control, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom.ORCID 0000-0002-0834-8488
Konstantinos T KonstantinidisCivil and Environmental Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, Georgia 30332, United States of America.
Karen LevyEnvironmental and Occupational Health Sciences, University of Washington, 2980 15th Ave NE, Seattle, Washington 98195, United States of America.
Rassul NaláMinistério da Saúde, Instituto Nacional de Saúde Maputo, Maputo, Mozambique.
Benjamin B RiskDepartment of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322, United States of America.
Jill StewartDepartment of Environmental Sciences and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States of America.ORCID 0000-0002-3474-5233
Joe BrownDepartment of Environmental Sciences and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States of America.ORCID 0000-0002-5200-4148

Funding

Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
NIEHS NIH HHS T32 ES007018
6 · The paper itself

Abstract

Environmental fecal contamination is common in many low-income cities, contributing to a high burden of enteric infections and associated negative sequelae. To evaluate the impact of a shared onsite sanitation intervention in Maputo, Mozambique on enteric pathogens in the domestic environment, we collected 179 soil samples at shared latrine entrances from intervention (n = 49) and control (n = 51) compounds during baseline (preintervention) and after 24 months (postintervention) as part of the Maputo Sanitation Trial. We tested soils for the presence of nucleic acids associated with 18 enteric pathogens using a multiplex reverse transcription qPCR platform. We detected at least one pathogen-associated gene target in 91% (163/179) of soils and a median of 3 (IQR = 1, 5) pathogens. Using a difference-in-difference analysis and adjusting for compound population, visibly wet soil, sun exposure, wealth, temperature, animal presence, and visible feces, we estimate the intervention reduced the probability of detecting ≥1 pathogen gene by 15% (adjusted prevalence ratio, aPR = 0.85; 95% CI: 0.70, 1.0) and the total number of pathogens by 35% (aPR = 0.65; 0.44, 0.95) in soil 24 months following the intervention. These results suggest that the intervention reduced the presence of some fecal contamination in the domestic environment, but pathogen detection remained prevalent 24 months following the introduction of new latrines.

Indexed as

SanitationSoilAnimalsCitiesFecesToilet FacilitiesSoilexposurefecal sludge managementlatrinesonsite sanitationurban slum

Identifiers

PMID34236178
PMCPMC8327413

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.