ArticleJCI insight2021
Reduced thyroxine production in young household contacts of tuberculosis patients increases active tuberculosis disease risk.
Article in JCI insight, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- MicroRNA-1246 regulates macrophage lipid metabolism and is involved in resistance to human Mycobacterium tuberculosis infection.PLoS pathogens · 2026Article
- Case Report: Concurrent thyroid tuberculosis and tuberculous lymphadenitis initially misdiagnosed as malignancy byFrontiers in surgery · 2026Article
- Defective IL-17 production is associated with reduced IL-1β levels in response toFrontiers in immunology · 2026Article
- Unmasking tuberculous lymphadenitis in a middle-aged male with Hashimoto's thyroiditis: a case report.AME case reports · 2025Article
- L-Thyroxine and L-thyroxine-based antimicrobials against Streptococcus pneumoniae and other Gram-positive bacteria.Heliyon · 2024Article
- Correlation between a low serum free triiodothyronine level and mortality of severe pulmonary tuberculosis patients.BMC infectious diseases · 2024Article
- Polyserositis caused by tuberculosis in a young female patient with hypothyroidism: A diagnostic challenge.Clinical case reports · 2023Article
- Bidirectional Relationship Between Tuberculosis and Hypothyroidism: An 18-Year Nationwide Population-Based Longitudinal Cohort Study.Frontiers in medicine · 2022Article
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Authors and funding
14 authors.
Funding
Abstract
In the current study, we followed 839 household contacts (HHCs) of tuberculosis (TB) patients for 2 years and identified the factors that enhanced the development of TB. Fourteen of the 17 HHCs who progressed to TB were in the 15- to 30-year-old age group. At baseline (the "0" time point, when all the individuals were healthy), the concentration of the thyroid hormone thyroxine (T4) was lower, and there were increased numbers of Tregs in PBMCs of TB progressors. At baseline, PBMCs from TB progressors stimulated with early secretory antigenic target 6 (ESAT-6) and 10 kDa culture filtrate antigen (CFP-10) produced less IL-1α. Thyroid hormones inhibited Mycobacterium tuberculosis (Mtb) growth in macrophages in an IL-1α-dependent manner. Mtb-infected Thra1PV/+ (mutant thyroid hormone receptor) mice had increased mortality and reduced IL-1α production. Our findings suggest that young HHCs who exhibit decreased production of thyroid hormones are at high risk of developing active TB disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.