Evidence map›Paper›PMID 34236003›Full record

SynthesisSports health

Neurocognitive and Neurophysiological Functions Related to ACL Injury: A Framework for Neurocognitive Approaches in Rehabilitation and Return-to-Sports Tests.

Daghan Piskin, Anne Benjaminse, Panagiotis Dimitrakis, Alli Gokeler

Registry-linked trialOpen access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Sports health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06797102 (Comparative Effects of Neuromuscular Training Vs Close Chain Exercises in Athletes With Post Operative ACL Injury), which is not on this map. Cited by 41 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 4 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06797102 nacompletednot on this map

Comparative Effects of Neuromuscular Training Vs Close Chain Exercises in Athletes With Post Operative ACL Injury

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2024Enrolled36ConditionsSports Physical TherapyArmsNeuromuscular Exercises, Close Chain Exercises
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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  11. Return to performance criteria in soccer after musculoskeletal injury: A scoping review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
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  15. Current Concepts in Hip and Core Assessment to Reduce the Risk of ACL Injury.International journal of sports physical therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Daghan PiskinExercise Science and Neuroscience Unit, Department Exercise and Health, University of Paderborn, Paderborn, Germany.
Anne BenjaminseCenter for Human Movement Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Panagiotis DimitrakisCenter for Human Movement Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Alli GokelerExercise Science and Neuroscience Unit, Department Exercise and Health, University of Paderborn, Paderborn, Germany.
University Medical Center Groningen · NLHealth & Safety in Sports · NLPaderborn University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextOnly 55% of the athletes return to competitive sports after an anterior cruciate ligament (ACL) injury. Athletes younger than 25 years who return to sports have a second injury rate of 23%. There may be a mismatch between rehabilitation contents and the demands an athlete faces after returning to sports. Current return-to-sports (RTS) tests utilize closed and predictable motor skills; however, demands on the field are different. Neurocognitive functions are essential to manage dynamic sport situations and may fluctuate after peripheral injuries. Most RTS and rehabilitation paradigms appear to lack this aspect, which might be linked to increased risk of second injury.

objectiveThis systematic and scoping review aims to map existing evidence about neurocognitive and neurophysiological functions in athletes, which could be linked to ACL injury in an integrated fashion and bring an extensive perspective to assessment and rehabilitation approaches. DATA SOURCES: PubMed and Cochrane databases were searched to identify relevant studies published between 2005 and 2020 using the keywords STUDY SELECTION: Studies investigating either neurocognitive or neurophysiological functions in athletes and linking these to ACL injury regardless of their design and technique were included. STUDY

designSystematic review. LEVEL OF EVIDENCE: Level 3. DATA EXTRACTION: The demographic, temporal, neurological, and behavioral data revealing possible injury-related aspects were extracted and summarized.

resultsA total of 16 studies were included in this review. Deficits in different neurocognitive domains and changes in neurophysiological functions could be a predisposing risk factor for, or a consequence caused by, ACL injuries.

conclusionClinicians should view ACL injuries not only as a musculoskeletal but also as a neural lesion with neurocognitive and neurophysiological aspects. Rehabilitation and RTS paradigms should consider these changes for assessment and interventions after injury.

Indexed as

Anterior Cruciate Ligament InjuriesAnterior Cruciate Ligament ReconstructionReinjuriesAthletesHumansReturn to Sportanterior cruciate ligament injuryathletescognitioncortical activityneuronal plasticity

Identifiers

PMID34236003
PMCPMC9214902
OpenAlexW3180132886

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.