ArticleEnvironmental science & technology2021
Uptake and Toxicity of Respirable Carbon-Rich Uranium-Bearing Particles: Insights into the Role of Particulates in Uranium Toxicity.
Article in Environmental science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Toxicity, Cellular Uptake, and Intracellular Fate of Particulate and Dissolved Uranium in Murine Lung-Relevant Cell Models.ACS omega · 2026Article
- Migration and Accumulation of Uranium-Associated Heavy Metals in Mining-Affected Ecosystems (Water, Soil, and Plants).Biology · 2026Review
- Extracellular vesicle proteomic expression is influenced by mining tenure in former uranium miners.Environmental research · 2025Article
- Changes in Dissolved Natural Organic Matter Composition Induced by Reaction with U(VI) at Acidic and Neutral pH.ACS ES&T water · 2025Article
- In vitro toxicity assessment of uranium particulates on different human lung epithelial cell models.PloS one · 2025Article
- Uranium accumulation in environmentally relevant microplastics and agricultural soil at acidic and circumneutral pH.The Science of the total environment · 2024Article
- Photoaging of polystyrene microspheres causes oxidative alterations to surface physicochemistry and enhances airway epithelial toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Article
- Health Effects of Particulate Uranium Exposure.Toxics · 2022Review
- Uranium: The Nuclear Fuel Cycle and Beyond.International journal of molecular sciences · 2022Review
- From Adsorption to Precipitation of U(VI): What is the Role of pH and Natural Organic Matter?Environmental science & technology · 2021Article
Corrections and comments
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Authors and funding
19 authors at 2 institutions in 2 countries.
Funding
Abstract
Particulate matter (PM) presents an environmental health risk for communities residing close to uranium (U) mine sites. However, the role of the particulate form of U on its cellular toxicity is still poorly understood. Here, we investigated the cellular uptake and toxicity of C-rich U-bearing particles as a model organic particulate containing uranyl citrate over a range of environmentally relevant concentrations of U (0-445 μM). The cytotoxicity of C-rich U-bearing particles in human epithelial cells (A549) was U-dose-dependent. No cytotoxic effects were detected with soluble U doses. Carbon-rich U-bearing particles with a wide size distribution (<10 μm) presented 2.7 times higher U uptake into cells than the particles with a narrow size distribution (<1 μm) at 100 μM U concentration. TEM-EDS analysis identified the intracellular translocation of clusters of C-rich U-bearing particles. The accumulation of C-rich U-bearing particles induced DNA damage and cytotoxicity as indicated by the increased phosphorylation of the histone H2AX and cell death, respectively. These findings reveal the toxicity of the particulate form of U under environmentally relevant heterogeneous size distributions. Our study opens new avenues for future investigations on the health impacts resulting from environmental exposures to the particulate form of U near mine sites.
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Registered trials
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