GuidelineArthritis care & research2021
2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Polyarteritis Nodosa.
Guideline in Arthritis care & research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Cutaneous Pediatric Vasculitis: A Clinico-Histopathological Overview of Common and Novel Entities.Dermatopathology (Basel, Switzerland) · 2026Review
- Rare Systemic Vasculitides: Polyarteritis Nodosa and Takayasu Arteritis.The American journal of case reports · 2026Article
- Aseptic meningitis as an uncommon presentation of polyarteritis nodosa: a case report with focused literature synthesis.BMC neurology · 2026Review
- Systemic Idiopathic Polyarteritis Nodosa Mimicking Cryoglobulinemic Vasculitis: A Diagnostic Challenge.Cureus · 2026Article
- Temporal artery biopsy in polyarteritis nodosa: a case-based narrative literature review.Clinical rheumatology · 2026Review
- Isaacs syndrome associated with polyarteritis nodosa.BMJ case reports · 2026Article
- Article
- Case Report: Tocilizumab as time-limited induction therapy enabling steroid withdrawal and conventional maintenance in refractory cutaneous polyarteritis nodosa.Frontiers in medicine · 2026Article
- MRI-guided muscle biopsy improves diagnostic yield in small- to medium-vessel vasculitis: a retrospective single-center study.Rheumatology international · 2025Article
- Takayasu Arteritis in a 55-Year-Old Woman With PriorClinical case reports · 2025Article
- Article
- New avenues in childhood vasculitis.Pediatric rheumatology online journal · 2025Review
- Cardiac disease in patients with vasculitis.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Critical Limb Threatening Ischemia Due to Severe Polyarteritis Nodosa.Internal medicine (Tokyo, Japan) · 2025Article
- Vasculitis in Children.Turkish archives of pediatrics · 2024Review
- Central Nervous System Involvement in Systemic Autoimmune Rheumatic Diseases-Diagnosis and Treatment.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Article
- Comprehensive Management of Vasculitis and Suspected Polyarteritis Nodosa in an Older Patient.Cureus · 2023Article
- Rapidly Progressive Coronary Aneurysm: A Rare Case of Isolated Coronary Vasculitis With Recurrent Myocardial Infarction.JACC. Case reports · 2022Article
- Recent topics related to etiology and clinical manifestations of cutaneous arteritis.Frontiers in medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors.
Funding
Abstract
objectiveTo provide evidence-based recommendations and expert guidance for the management of systemic polyarteritis nodosa (PAN).
methodsTwenty-one clinical questions regarding diagnostic testing, treatment, and management were developed in the population, intervention, comparator, and outcome (PICO) format for systemic, non-hepatitis B-related PAN. Systematic literature reviews were conducted for each PICO question. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to assess the quality of evidence and formulate recommendations. Each recommendation required ≥70% consensus among the Voting Panel.
resultsWe present 16 recommendations and 1 ungraded position statement for PAN. Most recommendations were graded as conditional due to the paucity of evidence. These recommendations support early treatment of severe PAN with cyclophosphamide and glucocorticoids, limiting toxicity through minimizing long-term exposure to both treatments, and the use of imaging and tissue biopsy for disease diagnosis. These recommendations endorse minimizing risk to the patient by using established therapy at disease onset and identify new areas where adjunctive therapy may be warranted.
conclusionThese recommendations provide guidance regarding diagnostic strategies, use of pharmacologic agents, and imaging for patients with PAN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.