Evidence map›Paper›PMID 34235882›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

HOCl-Activated Aggregation of Gold Nanoparticles for Multimodality Therapy of Tumors.

Dongya Liu, Lingyan Liu, Feiyang Liu, Mengfan Zhang, Peng Wei, Tao Yi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 82 citations in OpenAlex.

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  13. Constructing Activatable Photosensitizers Using Covalently Modified Mesoporous Silica.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dongya LiuDepartment of Chemistry, Fudan University, Shanghai, 200438, China.
Lingyan LiuDepartment of Chemistry, Fudan University, Shanghai, 200438, China.
Feiyang LiuDepartment of Chemistry, Fudan University, Shanghai, 200438, China.
Mengfan ZhangDepartment of Chemistry, Fudan University, Shanghai, 200438, China.
Peng WeiState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China.
Tao YiDepartment of Chemistry, Fudan University, Shanghai, 200438, China.ORCID 0000-0002-3309-8556
Fudan University · CNDonghua University · CN

Funding

Fundamental Research Funds for the Central Universities 2232021A-06National Natural Science Foundation of China 21671043National Natural Science Foundation of China 21877013Shanghai Sailing Program 20YF1401100
6 · The paper itself

Abstract

Tumor microenvironment-responsive nanodrugs offer promising opportunities for imaging-guided precision therapy with reduced side effects. Considering that the antitumor effect is closely related to the size of the nanodrugs, it is particularly important to develop a therapeutic system with size adjustability in the tumor microenvironment, which is still a great challenge in the field of nanotheranostics. Herein, a reactive oxygen species (ROS)-activated aggregation strategy is reported for imaging-guided precision therapy of tumors. The ROS-activated nanoplatform is constructed based on gold nanoparticles (AuNPs) coated with an HOCl probe on its surface (namely, Au-MB-PEG NPs). The Au-MB-PEG NPs show high sensitivity toward HOCl, resulting in the modulation of surface charge and rapid aggregation of AuNPs, and simultaneous release of methylene blue as a photosensitizer for photodynamic therapy (PDT). In the tumor environment, the aggregated AuNPs ensure higher tumor accumulation and retention. Furthermore, the redshift of the absorption of aggregated AuNPs leads to activated photoacoustic imaging signals and photothermal therapy (PTT) under near-infrared irradiation. Au-MB-PEG NPs thus efficiently inhibit the tumor growth through combined PTT-PDT therapy. This work contributes to the design of stimuli-induced size-aggregation nanodrugs, thereby attaining advanced performance in cancer diagnosis and treatment.

Indexed as

AnimalsCell Line, TumorCombined Modality TherapyDisease Models, AnimalGoldLiver Neoplasms, ExperimentalMetal NanoparticlesMicePhotochemotherapyPhotosensitizing AgentsPolyethylene GlycolsTheranostic NanomedicineTumor MicroenvironmentGoldPhotosensitizing AgentsPolyethylene Glycolsgold nanoparticlesHOCl-activated aggregationphotoacoustic imagingphotodynamic therapyphotothermal therapy

Identifiers

PMID34235882
PMCPMC8425924
OpenAlexW3182475446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.