Evidence map›Paper›PMID 34235874›Full record

ArticleCancer medicine2021

Prevalence, trends, and outcomes of atrial fibrillation in hospitalized patients with metastatic cancer: findings from a national sample.

Hedong Han, Longpei Chen, Zhen Lin, Xin Wei, Wei Guo, Yamei Yu, Cheng Wu, Yang Cao, Jia He

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  10. Atrial fibrillation in cancer: thromboembolism and bleeding in daily practice.Research and practice in thrombosis and haemostasis · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Hedong HanDepartment of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
Longpei ChenDepartment of Medical Oncology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China.
Zhen LinDepartment of Health Statistics, Second Military Medical University, Shanghai, China.
Xin WeiDepartment of Cardiology, Virginia Commonwealth University, Richmond, VA, USA.
Wei GuoDepartment of Health Statistics, Second Military Medical University, Shanghai, China.
Yamei YuDepartment of Cardiology, Shanghai Changning District Central Hospital, Shanghai, China.
Cheng WuDepartment of Health Statistics, Second Military Medical University, Shanghai, China.
Yang CaoClinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.ORCID 0000-0002-3552-9153
Jia HeDepartment of Health Statistics, Second Military Medical University, Shanghai, China.ORCID 0000-0002-2338-9501
Second Military Medical University · CNKaiping Central Hospital · CNÖrebro University · SETongji University · CNVirginia Commonwealth University · US

Funding

National key research and development program of China 2017YFC0908005National Science and Technology Major Project 2017ZX09304030National Thirteenth Five Year Plan Major Special Project 2017ZX09304016
6 · The paper itself

Abstract

backgroundEpidemiological evidence regarding the link between cancer and atrial fibrillation (AF) are limited and outcomes of metastatic cancer comorbid with AF need to be elucidated.

objectiveThis study aims to evaluate the prevalence, temporal trends, and outcomes of AF in hospitalized metastatic cancer patients.

methodsThe National Inpatient Sample (NIS) database was used to identify adult patients with metastatic tumors from 2003 to 2014. We analyzed the trends in AF prevalence, in-hospital mortality, total cost, length of stay (LOS), and comorbidities pertaining to metastatic cancer. Multivariable-adjusted models were used to evaluate the association of AF with clinical factors, in-hospital mortality, total cost, and LOS.

resultsAmong 2,478,598 patients with metastatic cancer, 8.74% (216,737) were diagnosed with AF. The proportion of comorbid AF increased from 8.28% in 2003 to 10.06% in 2014 (p < 0.0001). Older age, white race, male, Medicare, higher income, larger hospital bed size, and urban teaching hospital were associated with higher AF occurrence. Among primary tumor sites, lung cancer experienced the highest odds of AF compared to other cancers. Patients with metastasis to lymph node and respiratory organ had higher odds of AF. In metastatic cancer, AF was associated with higher in-hospital mortality (odds ratio: 1.48; 95% confidence interval: 1.43-1.54), 18% longer LOS, and 19% higher cost.

conclusionsAF prevalence in metastatic cancer continues to increase from 2003 to 2014. AF is linked to poorer prognosis and higher healthcare resource utilization. As the population ages, optimal preventive and treatment management strategies are needed for metastatic cancer comorbid with AF.

Indexed as

AdolescentAdultAgedAtrial FibrillationComorbidityFemaleHospital CostsHospital MortalityHumansLength of StayMaleMiddle AgedNeoplasmsPrevalenceRisk FactorsUnited Statesatrial fibrillationcanceroutcomesprevalencetrends

Identifiers

PMID34235874
PMCPMC8366074
OpenAlexW3179759193

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.