GuidelineArthritis care & research2021
2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis.
Guideline in Arthritis care & research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Endovascular Therapy for Intracranial Giant Cell Arteritis : Systematic Review, Technical Considerations and the Effect of Intra-arterial Calcium Channel Blockers.Clinical neuroradiology · 2022Pooled it
- Norwegian society of rheumatology recommendations on diagnosis and treatment of patients with giant cell arteritis.Frontiers in medicine · 2022Pooled it
- Ultrasound, PET/CT or temporal artery biopsy for giant cell arteritis? A prospective diagnostic accuracy study (the GAME-study).Acta ophthalmologica · 2026Observational
- Granulomatous Diseases of the CNS: Aetiology, Neuroradiological Features and Clinical Findings.Clinical neuroradiology · 2026Review
- Transcatheter Aortic Valve Replacement in Aortic Regurgitation Secondary to Aortic Valvulitis.JACC. Case reports · 2026Article
- What is the optimum incision for superficial temporal artery biopsy? An anatomical study using body donors.Surgical and radiologic anatomy : SRA · 2026Article
- Article
- Methylprednisolone pulses are associated with faster remission in Giant Cell Arteritis: a multicentre inception cohort study.Arthritis research & therapy · 2026Observational
- Dynamic vascular changes on long-term ultrasound monitoring predict relapse in large-vessel giant cell arteritis.Arthritis research & therapy · 2026Article
- Construction and internal cohort verification of clinical-imaging-based nomogram for early diagnosis in Takayasu arteritis.Frontiers in medicine · 2026Article
- Janus Kinase inhibitors in the treatment of large vessel vasculitis: a systematic review and meta-analysis.Open medicine (Warsaw, Poland) · 2026Article
- Rurality and Delayed Diagnosis of Giant Cell Arteritis-A Single-Center Experience.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2025Article
- A Rare Case of Giant Cell Arteritis Affecting Two Giants: Pulmonary and Root of Aorta Aneurysm.Clinical case reports · 2025Article
- Insight Into the Role of NLRP3 Inflammasomes in Takayasu's Arteritis: Mechanisms and Targeted Pharmacotherapies.Reviews in cardiovascular medicine · 2025Review
- Real-World Analysis of Patient Characteristics, Adverse Events, and Economic Burden Among Patients with Giant Cell Arteritis Treated with Glucocorticoids.Rheumatology and therapy · 2025Article
- Intracranial Involvement of Giant Cell Arteritis Mimicking Intracranial Atherosclerotic Disease.Stroke · 2025Article
- Cardiac disease in patients with vasculitis.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Impact of early treatment on the relapse-free survival and glucocorticoid dosing in giant cell arteritis: a retrospective cohort study.Clinical rheumatology · 2025Article
- Takayasu arteritis-associated refractory hypertension induces nephrotic syndrome through glomerular microangiopathy.CEN case reports · 2025Article
- Dyspnea with Hemidiaphragm Elevation in a Patient with Giant Cell Arteritis.Internal medicine (Tokyo, Japan) · 2025Article
Corrections and comments
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Authors and funding
32 authors at 20 institutions in 2 countries.
Funding
Abstract
objectiveTo provide evidence-based recommendations and expert guidance for the management of giant cell arteritis (GCA) and Takayasu arteritis (TAK) as exemplars of large vessel vasculitis.
methodsClinical questions regarding diagnostic testing, treatment, and management were developed in the population, intervention, comparator, and outcome (PICO) format for GCA and TAK (27 for GCA, 27 for TAK). Systematic literature reviews were conducted for each PICO question. The Grading of Recommendations Assessment, Development and Evaluation methodology was used to rate the quality of the evidence. Recommendations were developed by the Voting Panel, comprising adult and pediatric rheumatologists and patients. Each recommendation required ≥70% consensus among the Voting Panel.
resultsWe present 22 recommendations and 2 ungraded position statements for GCA, and 20 recommendations and 1 ungraded position statement for TAK. These recommendations and statements address clinical questions relating to the use of diagnostic testing, including imaging, treatments, and surgical interventions in GCA and TAK. Recommendations for GCA include support for the use of glucocorticoid-sparing immunosuppressive agents and the use of imaging to identify large vessel involvement. Recommendations for TAK include the use of nonglucocorticoid immunosuppressive agents with glucocorticoids as initial therapy. There were only 2 strong recommendations; the remaining recommendations were conditional due to the low quality of evidence available for most PICO questions.
conclusionThese recommendations provide guidance regarding the evaluation and management of patients with GCA and TAK, including diagnostic strategies, use of pharmacologic agents, and surgical interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.