Evidence map›Paper›PMID 34235804›Full record

ArticleHead & neck2021

The cost of cure: Examining objective and subjective financial toxicity in head and neck cancer survivors.

Khalil Baddour, Mark Fadel, Meng Zhao, Michael Corcoran, Maryanna S Owoc, Teresa H Thomas, Lindsay M Sabik, Marci L Nilsen, Robert L Ferris, Leila J Mady

Open access · greenAbstract read
In one paragraph

Article in Head & neck, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Measuring financial toxicity in head and neck cancer: a systematic review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024
    Pooled it
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  11. Clinical and social determinants of survivorship clinic attendance in head and neck cancer.Journal of cancer survivorship : research and practice · 2025
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  14. Financial toxicity and its influencing factors in young and middle-aged cancer patients: a latent profile analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  17. Financial toxicity-related factors in patients with nasopharyngeal carfcinoma: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Khalil BaddourDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Mark FadelDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Meng ZhaoStrategic Analysis of Clinical Affairs, UPMC Insurance Services, Pittsburgh, Pennsylvania, USA.
Michael CorcoranStrategic Analysis of Clinical Affairs, UPMC Insurance Services, Pittsburgh, Pennsylvania, USA.
Maryanna S OwocDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Teresa H ThomasDepartment of Health Promotion and Development, University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania, USA.
Lindsay M SabikDepartment of Health Policy and Management, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA.
Marci L NilsenDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Robert L FerrisDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-6605-2071
Leila J MadyDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-2682-3297
University of Pittsburgh · USStrategic Analysis (United States) · USUniversity of Pennsylvania · US

Funding

WILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Greg M. Delgoffe · 2004 to 2026
$49.6M
Research Training in OtolaryngologyT32DC000066 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHNSON, JONAS T. · 2003 to 2017
$1.8M
NCI NIH HHS P50 CA097190NIDCD NIH HHS T32 DC000066
6 · The paper itself

Abstract

backgroundLittle is documented regarding objective financial metrics and their impact on subjective financial toxicity in head and neck cancer (HNC) survivors.

methodsIn a cross-sectional analysis, 71 survivors with available claims data for HNC-specific out-of-pocket expenses (OOPE) completed a survey including patient-reported, subjective financial toxicity outcome tools: the Comprehensive Score for financial Toxicity (COST) and the Financial Distress Questionnaire (FDQ).

resultsWorse COST scores were significantly associated with lower earnings at survey administration (coefficient = 3.79; 95% CI 2.63-4.95; p < 0.001); loss of earnings after diagnosis (coefficient = 6.03; 95% CI 0.53-11.52; p = 0.032); and greater annual OOPE as a proportion of earnings [log10(Annual OOPE:Earnings at survey): coefficient = -5.66; 95% CI -10.28 to -1.04; p = 0.017]. Similar results were found with FDQ.

conclusionFinancial toxicity is associated with particular socioeconomic characteristics which, if understood, would assist the development of pre-treatment screening tools to detect at-risk individuals and intervene early in the HNC cancer survivorship trajectory.

Indexed as

Cost of IllnessHead and Neck NeoplasmsCross-Sectional StudiesHealth ExpendituresHumansSurvivorsfinancial toxicityhead and neck cancerhealth expenditureshealth servicesmultidisciplinary researchout-of-pocket expensespatient-reported outcomessurvivorshiptreatment costs

Identifiers

PMID34235804
PMCPMC8973201
OpenAlexW3177860198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.