Evidence map›Paper›PMID 34235740›Full record

ArticleJournal of surgical oncology2021

Preoperative β-lactam antibiotic prophylaxis is superior to bacteriostatic alternatives in immediate expander-based breast reconstruction.

Travis J Miller, Austin C Remington, Dung H Nguyen, Geoffrey C Gurtner, Arash Momeni

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Travis J MillerDivision of Plastic & Reconstructive Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Austin C RemingtonSection of Plastic Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Dung H NguyenDivision of Plastic & Reconstructive Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Geoffrey C GurtnerDivision of Plastic & Reconstructive Surgery, Stanford University School of Medicine, Palo Alto, California, USA.
Arash MomeniDivision of Plastic & Reconstructive Surgery, Stanford University School of Medicine, Palo Alto, California, USA.ORCID http://orcid.org/0000-0002-6452-751X
Palo Alto University · USUniversity of Michigan · US

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
NCATS NIH HHS UL1 TR003142NCRR NIH HHS UL1 RR025744
6 · The paper itself

Abstract

backgroundStaged implant-based breast reconstruction is the most common reconstructive modality following mastectomy. Postoperative implant infections can have a significant impact on adjuvant oncologic care and reconstructive outcome. Here, we investigate the impact of β-lactam antibiotics (i.e., bactericidal) compared to alternative antibiotic agents on postoperative outcomes for implant-based breast reconstruction.

methodsA retrospective analysis of patients who underwent immediate sub-pectoral tissue expander placement with an inferior acellular dermal matrix (ADM) sling at a single institution between May 2008 and July 2018 was performed. Patient demographics, comorbidities, and complication rates were retrieved. The impact of antibiotic regimen on postoperative outcomes, including infection rate and reconstructive failure, was investigated.

resultsA total of 320 patients with a mean age and BMI of 48.2 years and 25.0 kg/m

conclusionThe use of β-lactam antibiotics for pre-/peri-operative prophylaxis is superior to alternative antibiotics with a bacteriostatic mechanism of action regarding rates of postoperative infection and reconstructive failure following immediate tissue expander-based breast reconstruction. Extended, that is, post-discharge, prophylaxis does not appear to be indicated, regardless of the antibiotic chosen.

Indexed as

AftercareAntibiotic Prophylaxisbeta-LactamsBreast NeoplasmsFemaleFollow-Up StudiesHumansMammaplastyMastectomyMiddle AgedPostoperative ComplicationsPrognosisRetrospective StudiesSurgical Wound InfectionTissue Expansion Devicesbeta-Lactamsantibiotic prophylaxisbreast reconstructionimplant-based reconstructiontissue expanderβ-lactam antibiotics

Identifiers

PMID34235740
PMCPMC8429203
OpenAlexW3180767788

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.