Evidence map›Paper›PMID 34235622›Full record

ArticleNeuroscience bulletin2022

Effect of Sodium Salicylate on Calcium Currents and Exocytosis in Cochlear Inner Hair Cells: Implications for Tinnitus Generation.

Ting Fan, Meng-Ya Xiang, Ruo-Qiao Zhou, Wen Li, Li-Qin Wang, Peng-Fei Guan, Geng-Lin Li, Yun-Feng Wang, Jian Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ting Fan *ENT Institute and Department of Otorhinolaryngology, EYE & ENT Hospital, Fudan University, Shanghai, 200031, China.
Meng-Ya Xiang *ENT Institute and Department of Otorhinolaryngology, EYE & ENT Hospital, Fudan University, Shanghai, 200031, China.
Ruo-Qiao ZhouENT Institute and Department of Otorhinolaryngology, EYE & ENT Hospital, Fudan University, Shanghai, 200031, China.
Wen LiENT Institute and Department of Otorhinolaryngology, EYE & ENT Hospital, Fudan University, Shanghai, 200031, China.
Li-Qin WangENT Institute and Department of Otorhinolaryngology, EYE & ENT Hospital, Fudan University, Shanghai, 200031, China.
Peng-Fei GuanENT Institute and Department of Otorhinolaryngology, EYE & ENT Hospital, Fudan University, Shanghai, 200031, China.
Geng-Lin LiENT Institute and Department of Otorhinolaryngology, EYE & ENT Hospital, Fudan University, Shanghai, 200031, China. genglin.li@fdeent.org.
Yun-Feng WangENT Institute and Department of Otorhinolaryngology, EYE & ENT Hospital, Fudan University, Shanghai, 200031, China. wyf80612@126.com.
Jian LiClinical Laboratory Center, Children's Hospital of Fudan University, Shanghai, 201102, China. lijianjulia@fudan.edu.cn.
Eye & ENT Hospital of Fudan University · CNChildren's Hospital of Fudan University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sodium salicylate is an anti-inflammatory medication with a side-effect of tinnitus. Here, we used mouse cochlear cultures to explore the effects of salicylate treatment on cochlear inner hair cells (IHCs). We found that IHCs showed significant damage after exposure to a high concentration of salicylate. Whole-cell patch clamp recordings showed that 1-5 mmol/L salicylate did not affect the exocytosis of IHCs, indicating that IHCs are not involved in tinnitus generation by enhancing their neuronal input. Instead, salicylate induced a larger peak amplitude, a more negative half-activation voltage, and a steeper slope factor of Ca

Indexed as

Hair Cells, Auditory, InnerTinnitusAnimalsCalciumExocytosisMiceSodium SalicylateCalciumSodium SalicylateCalcium currentCaV1.3 channelExocytosisInner hair cellSalicylateTinnitusWhole-cell patch clamp

Identifiers

PMID34235622
PMCPMC8782992
OpenAlexW3179422711

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.