ArticleBrain structure & function2022
Polygenic scores for handedness and their association with asymmetries in brain structure.
Article in Brain structure & function, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- The Association Between Laterality and Stroke Severity: A Cross-Sectional Study.Health science reports · 2026Article
- Assessing the link among laterality, sex and competitiveness to verify the evolutionarily stable strategy of handedness.Scientific reports · 2026Article
- Brain asymmetries from mid- to late life and hemispheric brain age.Nature communications · 2024Article
- Broadening the scope: Increasing phenotype diversity in laterality research.Frontiers in behavioral neuroscience · 2022Article
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Authors and funding
9 authors at 4 institutions in 1 country.
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Abstract
Handedness is the most widely investigated motor preference in humans. The genetics of handedness and especially the link between genetic variation, brain structure, and right-left preference have not been investigated in detail. Recently, several well-powered genome-wide association studies (GWAS) on handedness have been published, significantly advancing the understanding of the genetic determinants of left and right-handedness. In the present study, we estimated polygenic scores (PGS) of handedness-based on the GWAS by de Kovel and Francks (Sci Rep 9: 5986, 2019) in an independent validation cohort (n = 296). PGS reflect the sum effect of trait-associated alleles across many genetic loci. For the first time, we could show that these GWAS-based PGS are significantly associated with individual handedness lateralization quotients in an independent validation cohort. Additionally, we investigated whether handedness-derived polygenic scores are associated with asymmetries in gray matter macrostructure across the whole brain determined using magnetic resonance imaging. None of these associations reached significance after correction for multiple comparisons. Our results implicate that PGS obtained from large-scale handedness GWAS are significantly associated with individual handedness in smaller validation samples with more detailed phenotypic assessment.
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