Evidence map›Paper›PMID 34235439›Full record

ArticleRadiology. Artificial intelligence2021

Improved Classification of Benign and Malignant Breast Lesions Using Deep Feature Maximum Intensity Projection MRI in Breast Cancer Diagnosis Using Dynamic Contrast-enhanced MRI.

Qiyuan Hu, Heather M Whitney, Hui Li, Yu Ji, Peifang Liu, Maryellen L Giger

Abstract read
In one paragraph

Article in Radiology. Artificial intelligence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Clinical Application of Artificial Intelligence in Breast MRI.Journal of the Korean Society of Radiology · 2025
    Review
  12. Article
  13. AI Applications to Breast MRI: Today and Tomorrow.Journal of magnetic resonance imaging : JMRI · 2024
    Review
  14. Role of artificial intelligence in digital pathology for gynecological cancers.Computational and structural biotechnology journal · 2024
    Review
  15. Review
  16. Machine learning and new insights for breast cancer diagnosis.The Journal of international medical research · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiyuan HuDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637 (Q.H., H.M.W., H.L., M.L.G.); Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.); and Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China (Y.J., P.L.).ORCID https://orcid.org/0000-0002-3326-6441
Heather M WhitneyDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637 (Q.H., H.M.W., H.L., M.L.G.); Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.); and Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China (Y.J., P.L.).ORCID https://orcid.org/0000-0002-7258-1102
Hui LiDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637 (Q.H., H.M.W., H.L., M.L.G.); Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.); and Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China (Y.J., P.L.).ORCID https://orcid.org/0000-0003-3139-2898
Yu JiDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637 (Q.H., H.M.W., H.L., M.L.G.); Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.); and Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China (Y.J., P.L.).ORCID https://orcid.org/0000-0002-3741-5627
Peifang LiuDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637 (Q.H., H.M.W., H.L., M.L.G.); Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.); and Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China (Y.J., P.L.).ORCID https://orcid.org/0000-0002-7333-0110
Maryellen L GigerDepartment of Radiology, The University of Chicago, 5841 S Maryland Ave, MC2026, Chicago, IL 60637 (Q.H., H.M.W., H.L., M.L.G.); Department of Physics, Wheaton College, Wheaton, Ill (H.M.W.); and Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Medical University, Tianjin, China (Y.J., P.L.).ORCID https://orcid.org/0000-0001-5482-9728

Funding

Quantitative Image Analysis for Assessing Response to Breast Cancer TherapyU01CA195564 · NCI · UNIVERSITY OF CHICAGO · PI GIGER, MARYELLEN L. · 2015 to 2019
$2.5M
Assessment of Repeatability and Robustness of Radiomics in Breast Cancer ImagingR15CA227948 · NCI · WHEATON COLLEGE · PI WHITNEY, HEATHER M · 2019 to 2019
$397k
Protected Radiomics Analysis Commons for Deep Learning in Biomedical DiscoveryS10OD025081 · OD · UNIVERSITY OF CHICAGO · PI GIGER, MARYELLEN L. · 2018 to 2018
$339k
NCI NIH HHS R15 CA227948NCI NIH HHS U01 CA195564NIH HHS S10 OD025081
6 · The paper itself

Abstract

purposeTo develop a deep transfer learning method that incorporates four-dimensional (4D) information in dynamic contrast-enhanced (DCE) MRI to classify benign and malignant breast lesions. MATERIALS AND

methodsThe retrospective dataset is composed of 1990 distinct lesions (1494 malignant and 496 benign) from 1979 women (mean age, 47 years ± 10). Lesions were split into a training and validation set of 1455 lesions (acquired in 2015-2016) and an independent test set of 535 lesions (acquired in 2017). Features were extracted from a convolutional neural network (CNN), and lesions were classified as benign or malignant using support vector machines. Volumetric information was collapsed into two dimensions by taking the maximum intensity projection (MIP) at the image level or feature level within the CNN architecture. Performances were evaluated using the area under the receiver operating characteristic curve (AUC) as the figure of merit and were compared using the DeLong test.

resultsThe image MIP and feature MIP methods yielded AUCs of 0.91 (95% CI: 0.87, 0.94) and 0.93 (95% CI: 0.91, 0.96), respectively, for the independent test set. The feature MIP method achieved higher performance than the image MIP method (∆AUC 95% CI: 0.003, 0.051;

conclusionIncorporating 4D information in DCE MRI by MIP of features in deep transfer learning demonstrated superior classification performance compared with using MIP images as input in the task of distinguishing between benign and malignant breast lesions.

Identifiers

PMID34235439
PMCPMC8231792

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.