Evidence map›Paper›PMID 34235374›Full record

ArticleJournal of pancreatic cancer2021

Cholesterol and CDON Regulate Sonic Hedgehog Release from Pancreatic Cancer Cells.

Jennifer I Alexander, Esteban Martinez, Alberto Vargas, Daniel Zinshteyn, Valerie Sodi, Denise C Connolly, Tiffiney R Hartman, Alana M O'Reilly

Open access · goldAbstract read
In one paragraph

Article in Journal of pancreatic cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Lipid metabolism in pancreatic cancer treatment.World journal of clinical oncology · 2026
    Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jennifer I AlexanderMolecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Esteban MartinezMolecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Alberto VargasMolecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Daniel ZinshteynMolecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Valerie SodiMolecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Denise C ConnollyMolecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Tiffiney R HartmanRoberts Individualized Medical Genetics Center and the Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Alana M O'ReillyMolecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Fox Chase Cancer Center · USChildren's Hospital of Philadelphia · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
Mechanisms Controlling Epithelial HomeostasisR01HD065800 · NICHD · RESEARCH INST OF FOX CHASE CAN CTR · PI O'REILLY, ALANA M · 2010 to 2020
$3.9M
NCI NIH HHS P30 CA006927NICHD NIH HHS R01 HD065800
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CDONcholesterolpancreatic cancerSonic Hedgehog

Identifiers

PMID34235374
PMCPMC8252898
OpenAlexW3171321937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.