Evidence map›Paper›PMID 34235257›Full record

ArticleACS central science2021

Electrochemical Strategy for Low-Cost Viral Detection.

Marjon Zamani, James M Robson, Andy Fan, Michael S Bono, Ariel L Furst, Catherine M Klapperich

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 76 citations in OpenAlex.

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  17. Harnessing the evolving CRISPR/Cas9 for precision oncology.Journal of translational medicine · 2024
    Review
  18. Improving electrochemical hybridization assays with restriction enzymes.Chemical communications (Cambridge, England) · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marjon ZamaniDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.
James M RobsonDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.
Andy FanDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.
Michael S BonoDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.
Ariel L FurstDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-9583-9703
Catherine M KlapperichDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.
Boston University · USMassachusetts Institute of Technology · US

Funding

Novel Biosensors based on Mining Bacterial Transcription FactorsR01EB029795 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI GALAGAN, JAMES E, KLAPPERICH, CATHERINE M. · 2020 to 2024
$2.6M
NIBIB NIH HHS R01 EB029795
6 · The paper itself

Abstract

Sexually transmitted infections, including the human immunodeficiency virus (HIV) and the human papillomavirus (HPV), disproportionally impact those in low-resource settings. Early diagnosis is essential for managing HIV. Similarly, HPV causes nearly all cases of cervical cancer, the majority (90%) of which occur in low-resource settings. Importantly, infection with HPV is six times more likely to progress to cervical cancer in women who are HIV-positive. An inexpensive, adaptable point-of-care test for viral infections would make screening for these viruses more accessible to a broader set of the population. Here, we report a novel, cost-effective electrochemical platform using gold leaf electrodes to detect clinically relevant viral loads. We have combined this platform with loop-mediated isothermal amplification and a CRISPR-based recognition assay to detect HPV. Lower limits of detection were demonstrated down to 10

Identifiers

PMID34235257
PMCPMC8227598
OpenAlexW3161497511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.