Evidence map›Paper›PMID 34235166›Full record

ReviewFrontiers in nutrition2021

Bovine Colostrum and Its Potential for Human Health and Nutrition.

Ayşenur Arslan, Merve Kaplan, Hatice Duman, Ayşe Bayraktar, Melih Ertürk, Bethany M Henrick, Steven A Frese, Sercan Karav

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
22.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Pooled it
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  16. Osteopontin: Its Properties, Recent Studies, and Potential Applications.International journal of molecular sciences · 2025
    Review
  17. Lactoperoxidase: Properties, Functions, and Potential Applications.International journal of molecular sciences · 2025
    Review
  18. Article
  19. Article
  20. Lactoferrin: Properties and Potential Uses in the Food Industry.International journal of molecular sciences · 2025
    Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ayşenur ArslanDepartment of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Merve KaplanDepartment of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Hatice DumanDepartment of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Ayşe BayraktarDepartment of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Melih ErtürkUluova Dairy, Canakkale, Turkey.
Bethany M HenrickEvolve Biosystems, Inc. Davis, CA, United States.
Steven A FreseDepartment of Food Science and Technology, University of Nebraska Lincoln, Lincoln, NE, United States.
Sercan KaravDepartment of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Çanakkale Onsekiz Mart Üniversitesi · TRCanakkale Onsekiz Mart Universitesi Tip Fakultesi Hastanesi · TRLungLife AI (United States) · USUniversity of Nebraska–Lincoln · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colostrum is the first milk produced post-partum by mammals and is compositionally distinct from mature milk. Bovine colostrum has a long history of consumption by humans, and there have been a number of studies investigating its potential for applications in human nutrition and health. Extensive characterization of the constituent fractions has identified a wealth of potentially bioactive molecules, their potential for shaping neonatal development, and the potential for their application beyond the neonatal period. Proteins, fats, glycans, minerals, and vitamins are abundant in colostrum, and advances in dairy processing technologies have enabled the advancement of bovine colostrum from relative limitations of a fresh and unprocessed food to a variety of potential applications. In these forms, clinical studies have examined bovine colostrum as having the substantial potential to improve human health. This review discusses the macro-and micronutrient composition of colostrum as well as describing well-characterized bioactives found in bovine colostrum and their potential for human health. Current gaps in knowledge are also identified and future directions are considered in order to elevate the potential for bovine colostrum as a component of a healthy diet for a variety of relevant human populations.

Indexed as

bioactive proteinsbovine colostrumhuman healthinfantsoligosaccharides

Identifiers

PMID34235166
PMCPMC8255475
OpenAlexW3175101166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.