Evidence map›Paper›PMID 34234994›Full record

ArticleAmerican journal of nuclear medicine and molecular imaging2021

Preclinical development and characterisation of

Nicholas Cl Wong, Yina Cai, Levente K Meszaros, Hans-Jürgen Biersack, Gary Jr Cook, Hong Hoi Ting, Felix M Mottaghy

Registry-linked trialAbstract read
In one paragraph

Article in American journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04992715 (A Single-arm, Phase II Study to Evaluate PD-L1 Expression in Non-Small Cell Lung Cancer Using the 99mTc Labelled Anti-PD-L1 Single Domain Antibody), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04992715 phase2unknown statusnot on this mapstarted 2022, after this paper: background citation

A Single-arm, Phase II Study to Evaluate PD-L1 Expression in Non-Small Cell Lung Cancer Using the 99mTc Labelled Anti-PD-L1 Single Domain Antibody (NM-01)

TypeinterventionalSponsorNanoMab Technology (UK) LimitedRan2022 to 2023Enrolled15ConditionsNon-Small Cell Lung CancerArms[99mTc]-NM01 SPECT/CT
3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. PD-L1 imaging with [British journal of cancer · 2025
    Trial
  2. Review
  3. Review
  4. Review
  5. Review
  6. The promising potential of camelid nanobodies for nuclear medicine.European journal of nuclear medicine and molecular imaging · 2025
    Article
  7. Article
  8. Preclinical evaluation and preliminary clinical study ofCancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. [EJNMMI research · 2023
    Article
  15. Radioimmunotherapy study ofEJNMMI research · 2022
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicholas Cl WongNanoMab Technology Limited Shanghai, People's Republic of China.
Yina CaiNanoMab Technology Limited Shanghai, People's Republic of China.
Levente K MeszarosNanoMab Technology Limited Shanghai, People's Republic of China.
Hans-Jürgen BiersackDepartment of Nuclear Medicine, University Hospital Bonn Bonn, Germany.
Gary Jr CookKing's College London and Guy's and St Thomas' PET Centre, St Thomas' Hospital London, SE1 7EH, UK.
Hong Hoi TingNanoMab Technology Limited Shanghai, People's Republic of China.
Felix M MottaghyDepartment of Nuclear Medicine, University Hospital RWTH Aachen Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The level of expression of programmed cell death-1 (PD-1)/programmed death ligand-1 (PD-L1) is a predictive biomarker for cancer immunotherapy, however, its detection remains challenging due to tumour heterogeneity and the influence from the binding of therapeutic agents. We recently developed [

Indexed as

PD-L1radiolabellingsingle domain antibodySPECT/CT imagingtracer

Identifiers

PMID34234994
PMCPMC8255215

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.