ArticleAnimal cells and systems2021
Alteration of fear behaviors in sleep-deprived adolescent rats: increased fear expression and delayed fear extinction.
Article in Animal cells and systems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Learning, sleep replay and consolidation of contextual fear memories: A neural network model.PLoS computational biology · 2026Article
- Review
- Molecular Effects of Cornelian Cherry Fruit (Current issues in molecular biology · 2025Article
- The effects of a dual orexin receptor antagonist on fear extinction memory and sleep in mice: Implications for exposure therapy.Behavioural brain research · 2024Article
- The neural basis underlying female vulnerability to depressive disorders.Animal cells and systems · 2023Review
- Core clock gene,Animal cells and systems · 2023Article
- Short-term maintenance on a high-sucrose diet alleviates aging-induced sleep fragmentation inAnimal cells and systems · 2021Article
- Oxytocin-induced anxiogenic behavior in juvenile male rats.Animal cells and systems · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disruption of sleep due to acute or chronic stress can lead to changes in emotional memory processing. Sleep disturbances are highly prevalent in post-traumatic stress disorder (PTSD), but still, the contribution of sleep deprivation on the susceptibility to PTSD has received little attention. To determine whether rapid eye movement sleep deprivation (SD) alters the development of fear expression or fear-associated memory impairment in adolescent rats, we performed animal emotional behavior tests using an SD animal model with the flowerpot technique. SD rats showed an increase in locomotor activity frequency and a decrease in sucrose consumption compared to control rats. An increase in freezing behavior during shock trials was observed in SD rats. Noticeably, it was observed that when applying the SD condition after fear stimuli exposure, fear extinction was delayed more in SD rats than in control rats. Overall, these results indicate that SD in adolescent rats leads to increased locomotor activity and anhedonic behavior, as well as increased fear expression and delayed fear extinction, suggesting that SD would lead to increased severity of PTSD-like phenotype.
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Registered trials
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