Evidence map›Paper›PMID 34234876›Full record

ArticleDisease markers2021

CALCB rs3829222 T/T Genotype and Low Expression of CALCB Are High-Risk Factors for Adenoid Cystic Carcinoma of Salivary Gland.

Chaobin Dai, Bin Zhang, Yunyang Liao, Qicai Liu, Feiguang Wu, Xiaoting Lv, Kai Zeng, Xiaofeng Zhu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. CGRP: A New Endogenous Cell Stemness Maintenance Molecule.Oxidative medicine and cellular longevity · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chaobin DaiSchool and Hospital of Stomatology, Fujian Medical University, No. 246, Yangqiao Middle Road, Gulou District, Fuzhou, Fujian Province 350000, China.ORCID https://orcid.org/0000-0002-2455-6164
Bin ZhangSchool and Hospital of Stomatology, Fujian Medical University, No. 246, Yangqiao Middle Road, Gulou District, Fuzhou, Fujian Province 350000, China.ORCID https://orcid.org/0000-0001-6974-0611
Yunyang LiaoDepartment of Oral Maxillo-Facial Surgery, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, Fujian Province 350000, China.
Qicai LiuReproductive Medicine Center, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, Fujian Province 350000, China.ORCID https://orcid.org/0000-0003-1766-9395
Feiguang WuStandardized Training Base, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, Fujian Province 350000, China.
Xiaoting LvDepartment of Respiratory, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350004, China.ORCID https://orcid.org/0000-0003-4100-6401
Kai ZengDepartment of Anesthesia, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, Fujian Province 350000, China.ORCID https://orcid.org/0000-0002-4343-3207
Xiaofeng ZhuDepartment of Oral Maxillo-Facial Surgery, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, Fujian Province 350000, China.ORCID https://orcid.org/0000-0003-1079-6607
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the relationship between polymorphisms of calcitonin-related peptide gene II (beta-calcitonin gene-related peptide ( MATERIALS AND

methodsUsing the polymerase chain reaction (PCR) technique, the full-length amplification and genotype analysis of CALCB genes were performed in 39 patients with adenoid cystic carcinoma of salivary gland and 158 normal controls. The gene frequencies of major genotype of CALCB in adenoid cystic carcinoma of salivary gland and normal control group were analyzed. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate serum calcitonin gene-related peptide (CGRP) and its concentration of alpha and beta subtypes.

resultsUnivariate logistic regression analysis showed that the CALCB rs2839222 T/T genotype was closely related to the occurrence of salivary adenoid cystic carcinoma, with a correlation coefficient of 3.89.

conclusionsThe serum CGRP concentration in the salivary adenoid cystic carcinoma group was 1.56 times that of the normal control group. The

Indexed as

GenotypePolymorphism, GeneticAdultAgedBiomarkers, TumorCalcitonin Gene-Related PeptideCarcinoma, Adenoid CysticCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedRisk FactorsSalivary Gland NeoplasmsBiomarkers, TumorCALCB protein, humanCalcitonin Gene-Related Peptide

Identifiers

PMID34234876
PMCPMC8216808
OpenAlexW3166858721

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.