Evidence map›Paper›PMID 34234839›Full record

ArticleComputational and mathematical methods in medicine2021

A Calibrated Multiexit Neural Network for Detecting Urothelial Cancer Cells.

L Lilli, E Giarnieri, S Scardapane

Abstract read
In one paragraph

Article in Computational and mathematical methods in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

L LilliDepartment of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Italy.
E GiarnieriFaculty of Medicine and Psychology, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0002-2046-5505
S ScardapaneDepartment of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0003-0881-8344

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep convolutional networks have become a powerful tool for medical imaging diagnostic. In pathology, most efforts have been focused in the subfield of histology, while cytopathology (which studies diagnostic tools at the cellular level) remains underexplored. In this paper, we propose a novel deep learning model for cancer detection from urinary cytopathology screening images. We leverage recent ideas from the field of multioutput neural networks to provide a model that can efficiently train even on small-scale datasets, such as those typically found in real-world scenarios. Additionally, we argue that calibration (i.e., providing confidence levels that are aligned with the ground truth probability of an event) has been a major shortcoming of prior works, and we experiment a number of techniques to provide a well-calibrated model. We evaluate the proposed algorithm on a novel dataset, and we show that the combination of focal loss, multiple outputs, and temperature scaling provides a model that is significantly more accurate and calibrated than a baseline deep convolutional network.

Indexed as

Image Interpretation, Computer-AssistedNeural Networks, ComputerAlgorithmsCalibrationComputational BiologyDatabases, FactualDeep LearningHumansUrinary Bladder NeoplasmsUrineUrothelium

Identifiers

PMID34234839
PMCPMC8216797

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.