Evidence map›Paper›PMID 34234786›Full record

ArticleFrontiers in immunology2021

A Straightforward Method for 3D Visualization of B Cell Clusters and High Endothelial Venules in Lymph Nodes Highlights Differential Roles of TNFRI and -II.

Kim C M Jeucken, Jasper J Koning, Jan Piet van Hamburg, Reina E Mebius, Sander W Tas

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kim C M JeuckenDepartment of Experimental Immunology, Amsterdam Institute for Infection & Immunity, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, Netherlands.
Jasper J KoningDepartment of Molecular Cell Biology and Immunology, Amsterdam Infection & Immunity Institute, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Jan Piet van HamburgDepartment of Experimental Immunology, Amsterdam Institute for Infection & Immunity, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, Netherlands.
Reina E MebiusDepartment of Molecular Cell Biology and Immunology, Amsterdam Infection & Immunity Institute, Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Sander W TasDepartment of Experimental Immunology, Amsterdam Institute for Infection & Immunity, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, Netherlands.
University of Amsterdam · NLVrije Universiteit Amsterdam · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whole mount tissue immunolabeling and imaging of complete organs has tremendous benefits in characterizing organ morphology. Here, we present a straightforward method for immunostaining, clearing and imaging of whole murine peripheral lymph nodes (PLNs) for detailed analysis of their architecture and discuss all procedures in detail in a step-by-step approach. Given the importance of tumor necrosis factor receptor (TNFR) signaling in development of PLNs we used TNFRI

Indexed as

Histological TechniquesAnimalsB-LymphocytesImage Processing, Computer-AssistedImaging, Three-DimensionalLymphatic VesselsLymph NodesMiceMice, Inbred C57BLMice, KnockoutReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIB cell clustershigh endothelial venulesperipheral lymph nodestissue clearing and labeling techniquetumor necrosis factor receptor superfamilywhole mount histology

Identifiers

PMID34234786
PMCPMC8255985
OpenAlexW3173286260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.