Evidence map›Paper›PMID 34234777›Full record

ReviewFrontiers in immunology2021

The OX40/OX40L Axis Regulates T Follicular Helper Cell Differentiation: Implications for Autoimmune Diseases.

NanNan Fu, Fang Xie, ZhongWen Sun, Qin Wang

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Combined TNF-α and OX40L targeting as a new treatment option for hidradenitis suppurativa.The journal of allergy and clinical immunology. Global · 2025
    Article
  15. Article
  16. Tolerogenic Therapies in Cardiac Transplantation.International journal of molecular sciences · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

NanNan FuSchool of Biology & Basic Medical Sciences, Medical College of Soochow University, Suzhou, China.
Fang XieSchool of Biology & Basic Medical Sciences, Medical College of Soochow University, Suzhou, China.
ZhongWen SunDepartment of Medical Technology, Suzhou Vocational Health College, Suzhou, China.
Qin WangSchool of Biology & Basic Medical Sciences, Medical College of Soochow University, Suzhou, China.
Soochow University · CNSuzhou Vocational Health College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T Follicular helper (Tfh) cells, a unique subset of CD4

Indexed as

AnimalsAutoimmune DiseasesCell DifferentiationGerminal CenterHumansLymphocyte ActivationOX40 LigandReceptors, OX40Signal TransductionT-Lymphocytes, Helper-InducerOX40 LigandReceptors, OX40autoimmune diseasesdifferentiationOX40OX40LTfh cells

Identifiers

PMID34234777
PMCPMC8256170
OpenAlexW3177041693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.