Evidence map›Paper›PMID 34234775›Full record

ArticleFrontiers in immunology2021

Early p38 Activation Regulated by MKP-1 Is Determinant for High Levels of IL-10 Expression Through TLR2 Activation.

Sara Francisco, Alicia Arranz, Javier Merino, Carmen Punzón, Rosario Perona, Manuel Fresno

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Gut microbes · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sara FranciscoDIOMUNE S. L., Parque Científico de Madrid, Madrid, Spain.
Alicia ArranzCentro de Biología Molecular "Severo Ochoa", Consejo Superior de Investigaciones Cientificas (CSIC)-Universidad Autónoma de Madrid, Madrid, Spain.
Javier MerinoDIOMUNE S. L., Parque Científico de Madrid, Madrid, Spain.
Carmen PunzónDIOMUNE S. L., Parque Científico de Madrid, Madrid, Spain.
Rosario PeronaInstituto de Investigaciones Biomedicas, Alberto Sols Universidad Autónoma de Madrid, Madrid, Spain.
Manuel FresnoDIOMUNE S. L., Parque Científico de Madrid, Madrid, Spain.
Universidad Autónoma de Madrid · ESCentro de Biología Molecular Severo Ochoa · ESUnidades Centrales Científico-Técnicas · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toll-like receptors (TLRs) play a crucial role in the recognition of pathogen-derived components as a first line of defense against infections. It has been suggested that depending on the nature of the pathogens, TLRs activation induce a distinct cytokine profile that may contribute to the polarization of the acquired immune response. Here, we investigated the early MAPK signaling activation

Indexed as

AnimalsCells, CulturedCytokinesDiglyceridesDual Specificity Phosphatase 1Enzyme ActivationGene ExpressionInterleukin-10LipopeptidesLipopolysaccharidesMacrophagesMiceMice, Inbred C57BLMice, KnockoutOligopeptidesp38 Mitogen-Activated Protein KinasesCytokinesDiglyceridesDual Specificity Phosphatase 1FSL-1 lipoprotein, syntheticInterleukin-10LipopeptidesLipopolysaccharidesOligopeptidesp38 Mitogen-Activated Protein KinasesPam(3)CSK(4) peptideToll-Like Receptor 2Toll-Like Receptor 4cytokinesinnate immunitymacrophagesMAPK signalingtoll-like receptors

Identifiers

PMID34234775
PMCPMC8256158
OpenAlexW3174817724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.