Evidence map›Paper›PMID 34234733›Full record

ArticleFrontiers in neurology2021

Angiogenin in the Neurogenic Subventricular Zone After Stroke.

Marina Gabriel-Salazar, Ting Lei, Alba Grayston, Carme Costa, Esperanza Medina-Gutiérrez, Manuel Comabella, Joan Montaner, Anna Rosell

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Article
  4. Observational
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marina Gabriel-SalazarNeurovascular Research Laboratory and Neurology Service, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Ting LeiNeurovascular Research Laboratory and Neurology Service, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Alba GraystonNeurovascular Research Laboratory and Neurology Service, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Carme CostaServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Vall d'Hebron Research Institute, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Esperanza Medina-GutiérrezNeurovascular Research Laboratory and Neurology Service, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Manuel ComabellaServei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat) and Vall d'Hebron Research Institute, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Joan MontanerNeurovascular Research Laboratory and Neurology Service, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Anna RosellNeurovascular Research Laboratory and Neurology Service, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Vall d'Hebron Institut de Recerca · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is a leading cause of death and disability worldwide with effective acute thrombolytic treatments. However, brain repair mechanisms related to spontaneous or rehabilitation-induced recovery are still under investigation, and little is known about the molecules involved. The present study examines the potential role of angiogenin (ANG), a known regulator of cell function and metabolism linked to neurological disorders, focusing in the neurogenic subventricular zone (SVZ). Angiogenin expression was examined in the mouse SVZ and in SVZ-derived neural stem cells (NSCs), which were exposed to exogenous ANG treatment during neurosphere formation as well as in other neuron-like cells (SH-SY5Y). Additionally, male C57Bl/6 mice underwent a distal permanent occlusion of the middle cerebral artery to study endogenous and exercise-induced expression of SVZ-ANG and neuroblast migration. Our results show that SVZ areas are rich in ANG, primarily expressed in DCX+ neuroblasts but not in nestin+NSCs.

Indexed as

angiogeninexerciseneural stem/progenitor cellsneurogenesisneurorepairstroke

Identifiers

PMID34234733
PMCPMC8256153
OpenAlexW3173353674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.