Evidence map›Paper›PMID 34234657›Full record

ArticleFrontiers in human neuroscience2021

Improved Pre-attentive Processing With Occipital rTMS Treatment in Major Depressive Disorder Patients Revealed by MMN.

Muzhen Guan, Xufeng Liu, Li Guo, Ruiguo Zhang, Qingrong Tan, Huaihai Wang, Huaning Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Muzhen GuanDepartment of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, China.
Xufeng LiuSchool of Military Medical Psychology, Air Force Medical University, Xi'an, China.
Li GuoDepartment of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, China.
Ruiguo ZhangDepartment of Psychiatry, Xi'an No. 3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, China.
Qingrong TanDepartment of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, China.
Huaihai WangDepartment of Psychiatry, Xi'an Union Hospital, Xi'an, China.
Huaning WangDepartment of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, China.
Air Force Medical University · CNXijing Hospital · CNNorthwest University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the improvement effect of occipital repetitive transcranial magnetic stimulation (rTMS) combined with escitalopram oxalate tablets on pre-attentive processing in patients with first-episode, medication-naive depression.

methodsPatients who were hospitalized between January and December 2019 were selected. They were randomly allocated to real occipital rTMS stimulation group with 27 cases receiving intermittent theta-burst (iTBS) and sham stimulation group with 24 cases over 20 days. The rTMS treatment target is located at the Oz point of the occipital region. Both groups took escitalopram oxalate tablets, and the average daily drug dose was 15.294 ± 5.041 mg. Hamilton Depression Rating Scale (HAMD) was used to assess the symptoms of depression before and after treatment, and mismatch negativity (MMN) was used to assess the improvement of pre-attentive processing before and after treatment.

resultsAfter 20 days of treatment, the total score of HAMD (13.495 ± 3.700) in both groups was significantly lower than that before treatment [21.910 ± 3.841,

conclusionOccipital rTMS treatment can enhance the early therapeutic effect and effectively improve the pre-attentive processing of patients with depression and provide a scientific basis for the new target of rTMS therapy in clinical patients with depression.

Indexed as

event-related potentialsmajor depressive disordermismatch negativityoccipital loberepetitive transcranial magnetic stimulation

Identifiers

PMID34234657
PMCPMC8256852
OpenAlexW3168491597

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.