ArticleBioinformation2021
Molecular docking analysis of stachydrine and sakuranetin with IL-6 and TNF-α in the context of inflammation.
Article in Bioinformation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
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- Exploring the potential therapeutic benefits of 7-methoxy coumarin for neuropathy pain: an in vivo, in vitro, and in silico approach.Molecular biology reports · 2024Article
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- Computational Exploration of Single-Nucleotide Polymorphisms in the Human hRAS Gene: Implications and Insights.Cureus · 2024Article
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Authors and funding
5 authors.
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Abstract
Inflammation is a process triggered by pro-inflammatory cytokines and anti-inflammatory molecules. Therefore, it is of interest to document the anti-inflammatory activity of Stachydrine and Sakuranetin against the inflammatory target proteins IL-6 and TNF-α by using molecular docking analysis. Both compounds showed good binding features with the selected target proteins. Compared to Sakuranetin, the Stachydrine have low binding energy and good hydrogen bond interactions. Hence, data show that Stachydrine possessed high and specific inhibitory activity on tumor necrosis factor-α and interleukin-6.
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