Evidence map›Paper›PMID 34234366›Full record

ArticlePloS one2021

Single-cell transcriptome analysis of the zebrafish embryonic trunk.

Sanjeeva Metikala, Satish Casie Chetty, Saulius Sumanas

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

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  15. c-Kit Receptor Maintains Sensory Axon Innervation of the Skin through Src Family Kinases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sanjeeva MetikalaDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America.ORCID 0000-0002-6774-6523
Satish Casie ChettyDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America.
Saulius SumanasDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America.ORCID 0000-0002-8605-6122
Cincinnati Children's Hospital Medical Center · US

Funding

Novel mechanisms of vasculogenesisR01HL153005 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SUMANAS, SAULIUS · 2021 to 2024
$2.0M
THE ROLE OF COLLAGEN COL22A1 IN INTRACRANIAL ANEURYSMS AND VASCULAR STABILITYR01HL134815 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SUMANAS, SAULIUS · 2017 to 2020
$1.8M
Characterization of a novel hematopoietic siteR21AI128445 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI SUMANAS, SAULIUS · 2017 to 2018
$429k
NHLBI NIH HHS R01 HL134815NHLBI NIH HHS R01 HL153005NIAID NIH HHS R21 AI128445
6 · The paper itself

Abstract

During embryonic development, cells differentiate into a variety of distinct cell types and subtypes with diverse transcriptional profiles. To date, transcriptomic signatures of different cell lineages that arise during development have been only partially characterized. Here we used single-cell RNA-seq to perform transcriptomic analysis of over 20,000 cells disaggregated from the trunk region of zebrafish embryos at the 30 hpf stage. Transcriptional signatures of 27 different cell types and subtypes were identified and annotated during this analysis. This dataset will be a useful resource for many researchers in the fields of developmental and cellular biology and facilitate the understanding of molecular mechanisms that regulate cell lineage choices during development.

Indexed as

Gene Expression ProfilingSingle-Cell AnalysisAnimalsCell LineageEctodermEmbryo, NonmammalianEndodermEndothelium, VascularErythrocytesFibroblastsGene Expression Regulation, DevelopmentalMesodermMuscle, SkeletalTorsoZebrafishZebrafish ProteinsZebrafish Proteins

Identifiers

PMID34234366
PMCPMC8263256
OpenAlexW3182116750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.