Evidence map›Paper›PMID 34234349›Full record

ArticleNature2021

Structure of human Ca

Shuai Gao, Xia Yao, Nieng Yan

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 157 citations in OpenAlex.

  1. Voltage-sensing domains: structural and functional diversity.European biophysics journal : EBJ · 2026
    Review
  2. Identification of novel functional sites in the CaProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Brain communications · 2026
    Article
  8. Review
  9. Efficacy and safety of the CaPain reports · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Nonsubstrate PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Review
  20. Hyperpolarization Modulation of the T-Type hCaAngewandte Chemie (International ed. in English) · 2025
    Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shuai Gao *Department of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-8734-2489
Xia Yao *Department of Molecular Biology, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0003-2406-268X
Nieng YanDepartment of Molecular Biology, Princeton University, Princeton, NJ, USA. nyan@princeton.edu.ORCID http://orcid.org/0000-0003-4829-7416
Princeton University · US

Funding

Structural investigation of the gating and regulatory mechanism of voltage-gated Ca2+ channelsR01GM130762 · NIGMS · PRINCETON UNIVERSITY · PI YAN, NIENG · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM130762NIH HHS 5R01 GM130762
6 · The paper itself

Abstract

The neuronal-type (N-type) voltage-gated calcium (Ca

Indexed as

Cryoelectron MicroscopyAnalgesics, Non-NarcoticCalcium Channel BlockersCalcium Channels, N-TypeHumansModels, Molecularomega-ConotoxinsPhosphatidylinositol 4,5-DiphosphateProtein ConformationProtein StabilityAnalgesics, Non-NarcoticCACNA1B protein, humanCalcium Channel BlockersCalcium Channels, N-Typeomega-ConotoxinsPhosphatidylinositol 4,5-Diphosphateziconotide

Identifiers

PMID34234349
PMCPMC8529174
OpenAlexW3178563513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.