ArticleNature2021
Metabolic control of T
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 130 citations in OpenAlex.
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- Biosynthesis of Phosphatidylethanolamine and Phosphatidylcholine via the Kennedy Pathway in Cancer and Other Pathological Conditions.International journal of molecular sciences · 2026Review
- Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics.Nature metabolism · 2026Article
- Structural Lipidomics Uncovers CC Location-Specific Lipid Signatures and the Response to Immune Checkpoint Inhibitor in dMMR/MSI‑H Colorectal Cancer.ACS measurement science au · 2026Article
- Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT.Nature biotechnology · 2026Article
- Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis.Molecular neurodegeneration · 2026Article
- Immune Regulatory and Underlying Mechanisms of Polysaccharides fromMolecules (Basel, Switzerland) · 2026Article
- Genetics of selenoproteins and selenoprotein metabolism - An overview of current concepts and emerging aspects.Redox biology · 2026Review
- In vivo CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation.The Journal of experimental medicine · 2026Article
- High-throughput screening to engineer optimal T cell therapies: current knowledge and future prospects.Frontiers in oncology · 2026Review
- The role of metabolic reprogramming in oocyte development: research progress and prospects.Frontiers in reproductive health · 2026Review
- Identification of plasma phosphatidylethanolamine species associated with myocardial infarction risk in patients with stable angina: A cross-sectional lipidomics study.The Journal of international medical research · 2025Article
- Multi-omics reveal beneficial effects of chrysanthemum stalks on growth performance and immune function in Hu sheep.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- CXCR5-engineered mesenchymal stromal cells home to spleen and mitigate post-sepsis syndrome by preventing secondary infection.Stem cell research & therapy · 2025Article
- The Pathogenic Role of T Cell Metabolism and its Effect on Immune Senescence in Autoimmune Diseases and Infection.Clinical reviews in allergy & immunology · 2025Review
- TCR signal-enhancing mutation alters lipid metabolism of thymocytes and impairs antitumor immunity of mature T cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Decoding adipose-brain crosstalk: Distinct lipid cargo in human adipose-derived extracellular vesicles modulates amyloid aggregation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Methods and applications of in vivo CRISPR screening.Nature reviews. Genetics · 2025Review
- Immune cells in systemic lupus erythematosus: biology and traditional Chinese medicine therapy.Acta pharmacologica Sinica · 2025Review
- Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection.Science advances · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 2 institutions in 1 country.
Guotong FuDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Clifford S GuyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Nicole M ChapmanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Gustavo PalaciosDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jun WeiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Peipei ZhouDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Lingyun LongDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yong-Dong WangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-8751-9216
Chenxi QianDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Yogesh DhunganaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hongling HuangDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Anil KcDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Hao ShiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-2796-629X
Sherri RankinDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Scott A BrownDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Amanda JohnsonCellular Imaging Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, USA.
Randall WakefieldCellular Imaging Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-6233-8109
Camenzind G RobinsonCellular Imaging Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-7277-692X
Xueyan LiuDepartment of Mathematics, University of New Orleans, New Orleans, LA, USA.
Anthony SheynDepartment of Surgery, Division of Otolaryngology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Jiyang YuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-3629-4330
Suzanne JackowskiDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-6855-1429
Hongbo ChiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. hongbo.chi@stjude.org.ORCID http://orcid.org/0000-0002-9997-2496
St. Jude Children's Research Hospital · USUniversity of New Orleans · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MRegulation of TH17 plasticity and stemness by mTORC1R01AI131703 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$4.1MTranscriptional and metabolic heterogeneity in T cell differentiationR01AI140761 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$3.9MMetabolic checkpoint in dendritic cell subsets and adaptive immunityR37AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.6MBidirectional signaling in T cell differentiationR01AI150241 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.3MNutrient sensing and lysosomal signaling in regulatory T cells and immune toleranceR01AI150514 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2019 to 2023
$2.2MMetabolic checkpoint in TH17 cell differentiationR01AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2014 to 2018
$2.2MIntracellular and Intercellular Network Rewiring and Hidden Driver Inference from Single-Cell DataR01GM134382 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YU, JIYANG · 2019 to 2023
$1.7MMetabolic reprogramming of Tregs in tumor immunityR01CA221290 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2017 to 2020
$1.6MNCI NIH HHS P30 CA021765NCI NIH HHS R01 CA221290NIAID NIH HHS R01 AI105887NIAID NIH HHS R01 AI131703NIAID NIH HHS R01 AI140761NIAID NIH HHS R01 AI150241NIAID NIH HHS R01 AI150514NIAID NIH HHS R37 AI105887NIGMS NIH HHS R01 GM134382
Abstract
T follicular helper (T
Indexed as
Immunity, HumoralAnimalsB-LymphocytesCell DifferentiationCRISPR-Cas SystemsCytidine DiphosphateFemaleGene Expression RegulationHumansLeukocytes, MononuclearLymphocyte ActivationMaleMiceMice, Inbred C57BLMice, TransgenicPhosphatidylethanolaminesCytidine Diphosphateethanolamine kinaseEthanolamine-phosphate cytidylyltransferasephosphatidylethanolaminePhosphatidylethanolaminesPhosphotransferases (Alcohol Group Acceptor)Receptors, CXCR5RNA Nucleotidyltransferases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.