Evidence map›Paper›PMID 34234345›Full record

ArticleNature2021

BANP opens chromatin and activates CpG-island-regulated genes.

Ralph S Grand, Lukas Burger, Cathrin Gräwe, Alicia K Michael, Luke Isbel, Daniel Hess, Leslie Hoerner, Vytautas Iesmantavicius, Sevi Durdu, Marco Pregnolato and 5 more

Open access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Editing epigenetic age.Nature aging · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. CRISPR-epigenetic crosstalk: From bidirectional regulation to therapeutic potential.Computational and structural biotechnology journal · 2025
    Review
  16. Dissecting thebioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Ralph S Grand *Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Lukas Burger *Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID http://orcid.org/0000-0001-5596-7567
Cathrin GräweDepartment of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.
Alicia K MichaelFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Luke IsbelFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID http://orcid.org/0000-0002-5270-4347
Daniel HessFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1642-5404
Leslie HoernerFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Vytautas IesmantaviciusFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Sevi DurduFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID http://orcid.org/0000-0001-9746-6779
Marco PregnolatoFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Arnaud R KrebsFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Sébastien A SmallwoodFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.
Nicolas ThomäFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID http://orcid.org/0000-0003-2685-906X
Michiel VermeulenDepartment of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-0836-6894
Dirk SchübelerFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland. dirk@fmi.ch.ORCID http://orcid.org/0000-0002-9229-2228
Friedrich Miescher Institute · CHRadboud University Nijmegen · NLUniversity of Basel · CHEuropean Molecular Biology Laboratory · DESIB Swiss Institute of Bioinformatics · CHUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The majority of gene transcripts generated by RNA polymerase II in mammalian genomes initiate at CpG island (CGI) promoters

Indexed as

Chromatin Assembly and DisassemblyAnimalsBase SequenceCell Cycle ProteinsCell Line, TumorChromatinCpG IslandsDNA-Binding ProteinsDNA MethylationGene Expression RegulationGenes, EssentialHumansMiceNuclear ProteinsSingle Molecule ImagingBANP protein, humanBanp protein, mouseCell Cycle ProteinsChromatinDNA-Binding ProteinsNuclear Proteins

Identifiers

PMID34234345
OpenAlexW3177586536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.