Evidence map›Paper›PMID 34234344›Full record

ArticleNature2021

Structural basis of early translocation events on the ribosome.

Emily J Rundlet, Mikael Holm, Magdalena Schacherl, S Kundhavai Natchiar, Roger B Altman, Christian M T Spahn, Alexander G Myasnikov, Scott C Blanchard

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
  2. RNAViruses · 2026
    Review
  3. Article
  4. Structural basis for emetine inhibition of ribosome translocation inbioRxiv : the preprint server for biology · 2026
    Article
  5. Evolution of a core ribosomal innovation in octopus.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. ACS chemical biology · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Multi-channel smFRET study reveals a compact conformation of EF-G on the ribosome.The international journal of biochemistry & cell biology · 2025
    Article
  13. Doublet decoding of tRNANature communications · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Specialized ribosomes: integrating new insights and current challenges.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Emily J RundletDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mikael HolmDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Magdalena SchacherlInstitut für Medizinische Physik und Biophysik, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-5478-2509
S Kundhavai NatchiarDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Roger B AltmanDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Christian M T SpahnInstitut für Medizinische Physik und Biophysik, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Alexander G MyasnikovDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-2607-7121
Scott C BlanchardDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. Scott.Blanchard@stjude.org.ORCID http://orcid.org/0000-0003-2717-9365
St. Jude Children's Research Hospital · USCharité - Universitätsmedizin Berlin · DE

Funding

Imaging Protein Synthesis on the Ribosome using Single-Molecule FRETR01GM079238 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANCHARD, SCOTT C · 2006 to 2023
$7.0M
Tri-Institutional PhD Program in Chemical BiologyT32GM115327 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TAN, DEREK S · 2015 to 2019
$741k
NIGMS NIH HHS R01 GM079238NIGMS NIH HHS T32 GM115327
6 · The paper itself

Abstract

Peptide-chain elongation during protein synthesis entails sequential aminoacyl-tRNA selection and translocation reactions that proceed rapidly (2-20 per second) and with a low error rate (around 10

Indexed as

Protein BiosynthesisCodonEscherichia coliEscherichia coli ProteinsModels, MolecularPeptide Elongation Factor GRibosomesRNA, MessengerRNA, Transfer, Amino AcylCodonEscherichia coli ProteinsPeptide Elongation Factor GRNA, MessengerRNA, Transfer, Amino AcyltRNA, peptidyl-

Identifiers

PMID34234344
PMCPMC8318882
OpenAlexW3179531496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.