Evidence map›Paper›PMID 34234285›Full record

ArticleThe Journal of antibiotics2021

6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone.

Katsuyuki Sakai, Risa Takao, Hiroyuki Koshino, Yushi Futamura, Hiroyuki Osada, Shunji Takahashi

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katsuyuki Sakai *Natural Product Biosynthesis Research Unit, RIKEN Centre for Sustainable Resource Science, Wako, Saitama, Japan.ORCID http://orcid.org/0000-0001-9210-6176
Risa Takao *Natural Product Biosynthesis Research Unit, RIKEN Centre for Sustainable Resource Science, Wako, Saitama, Japan.ORCID http://orcid.org/0000-0002-4269-9257
Hiroyuki KoshinoMolecular Structure Characterization Unit, Technology Platform Division, RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.ORCID http://orcid.org/0000-0002-0954-9839
Yushi FutamuraChemical Biology Research Group, RIKEN Centre for Sustainable Resource Science, Wako, Saitama, Japan.ORCID http://orcid.org/0000-0002-4224-6944
Hiroyuki OsadaChemical Biology Research Group, RIKEN Centre for Sustainable Resource Science, Wako, Saitama, Japan.ORCID http://orcid.org/0000-0002-3606-4925
Shunji TakahashiNatural Product Biosynthesis Research Unit, RIKEN Centre for Sustainable Resource Science, Wako, Saitama, Japan. shunjitaka@riken.jp.ORCID http://orcid.org/0000-0003-1684-9298

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel angucyclinone, 6,9-dihydroxytetrangulol, was isolated from Streptomyces lividans TK23 transformed with a kinanthraquinone biosynthetic gene cluster in which the kiqO gene was disrupted. The chemical structure was elucidated by spectroscopic analyses. It showed significant antibacterial activities with an IC

Indexed as

AnthraquinonesAnti-Bacterial AgentsAntineoplastic AgentsHL-60 CellsHumansInhibitory Concentration 50Multigene FamilyStaphylococcus aureusStreptomyces lividansangucyclinoneAnthraquinonesAnti-Bacterial AgentsAntineoplastic Agents

Identifiers

PMID34234285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.