Evidence map›Paper›PMID 34234207›Full record

ArticleScientific reports2021

Navigation of a magnetic micro-robot through a cerebral aneurysm phantom with magnetic particle imaging.

Anna C Bakenecker, Anselm von Gladiss, Hannes Schwenke, André Behrends, Thomas Friedrich, Kerstin Lüdtke-Buzug, Alexander Neumann, Joerg Barkhausen, Franz Wegner, Thorsten M Buzug

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
  2. Two-Photon Endomicroscopy for Image-Guided Magnetic Micro-Agents.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Article
  4. Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Review
  7. Magnetic Milli-Spinner for Robotic Endovascular Surgery.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. MOF Coating Enhances the Ion Tolerance of Micromotors.Angewandte Chemie (International ed. in English) · 2025
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Bare-Metal Stent Tracking with Magnetic Particle Imaging.International journal of nanomedicine · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Anna C BakeneckerInstitute of Medical Engineering, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany. bakenecker@imt.uni-luebeck.de.ORCID 0000-0002-9708-3476
Anselm von GladissInstitute of Medical Engineering, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.ORCID 0000-0003-1340-4576
Hannes SchwenkeDepartment of Neuroradiology, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
André BehrendsInstitute of Medical Engineering, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Thomas FriedrichInstitute of Medical Engineering, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Kerstin Lüdtke-BuzugInstitute of Medical Engineering, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Alexander NeumannInstitute of Medical Engineering, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Joerg BarkhausenDepartment of Radiology and Nuclear Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Franz Wegner *Department of Radiology and Nuclear Medicine, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
Thorsten M Buzug *Institute of Medical Engineering, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany. thorsten.buzug@imte.fraunhofer.de.
University of Lübeck · DEFraunhofer Research Institution for Individualized and Cell-Based Medical Engineering · DEUniversity Hospital Schleswig-Holstein · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.

Indexed as

Phantoms, ImagingRobotic Surgical ProceduresDiagnostic ImagingHumansHyperthermia, InducedImage Processing, Computer-AssistedImaging, Three-DimensionalIntracranial AneurysmSurgery, Computer-AssistedTomography, X-Ray ComputedTreatment Outcome

Identifiers

PMID34234207
PMCPMC8263782
OpenAlexW3178193339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.