ArticleScientific reports2021
Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 66 citations in OpenAlex.
- Harnessing the sparing effect of FLASH-RT: From phenomenon observation, radiophysical determinants to molecular mechanisms and synergistic strategies.Materials today. Bio · 2026Review
- Macro Monte Carlo dose calculation for very high energy electron (VHEE) radiotherapy.Medical physics · 2026Article
- Multiscale Radiobiological Assessment of Laser-Driven Very High Energy Electrons Versus Conventional Electrons.Advances in radiation oncology · 2026Article
- Start-to-end modelling of laser-plasma acceleration, beam transport and dose deposition of very high-energy electrons for radiotherapy.Scientific reports · 2026Article
- Article
- Treatment planning comparison of focused very high energy electron and volumetric modulated arc therapy.Physics and imaging in radiation oncology · 2026Article
- Comparison of protons and very high-energy electrons transmission pencil-beam-scanning for FLASH radiotherapy.Physics and imaging in radiation oncology · 2025Article
- Clinical translation of ultra-high dose rate flash radiotherapy: Opportunities, challenges, and prospects.World journal of radiology · 2025Review
- Preparations for Ultra-High Dose Rate 25-90 MeV Electron Radiation Experiments with a Compact, High-Peak-Current, X-band Linear Accelerator.Radiation research · 2025Article
- Consensus statement on the exploration of clinical translation and application of electron ultra-high dose rate FLASH radiotherapy.Precision radiation oncology · 2025Article
- Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype.Nature communications · 2025Article
- On the acceptance, commissioning, and quality assurance of electron FLASH units.Medical physics · 2025Article
- Review
- Implementation and validation of a very-high-energy electron model in the matRad treatment planning system.Medical physics · 2025Article
- Optimizing focused very-high-energy electron beams for radiation therapy based on Monte Carlo simulation.Scientific reports · 2024Article
- Treatment planning for very high energy electrons: Studies that indicate the potential of the modality.Physics and imaging in radiation oncology · 2024Review
- FLASH radiotherapy: bridging revolutionary mechanisms and clinical frontiers in cancer treatment - a narrative review.Ewha medical journal · 2024Review
- CERN-based experiments and Monte-Carlo studies on focused dose delivery with very high energy electron (VHEE) beams for radiotherapy applications.Scientific reports · 2024Article
- Extending deterministic transport capabilities for very-high and ultra-high energy electron beams.Scientific reports · 2024Article
- Dosimetric characterization of a novel UHDR megavoltage X-ray source for FLASH radiobiological experiments.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
This paper presents the first demonstration of deeply penetrating dose delivery using focused very high energy electron (VHEE) beams using quadrupole magnets in Monte Carlo simulations. We show that the focal point is readily modified by linearly changing the quadrupole magnet strength only. We also present a weighted sum of focused electron beams to form a spread-out electron peak (SOEP) over a target region. This has a significantly reduced entrance dose compared to a proton-based spread-out Bragg peak (SOBP). Very high energy electron (VHEE) beams are an exciting prospect in external beam radiotherapy. VHEEs are less sensitive to inhomogeneities than proton and photon beams, have a deep dose reach and could potentially be used to deliver FLASH radiotherapy. The dose distributions of unfocused VHEE produce high entrance and exit doses compared to other radiotherapy modalities unless focusing is employed, and in this case the entrance dose is considerably improved over existing radiations. We have investigated both symmetric and asymmetric focusing as well as focusing with a range of beam energies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.