Observational studyNature communications2021
Translocation of vaginal microbiota is involved in impairment and protection of uterine health.
Observational study in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06962059 (Vaginal Metabolome Healthy Volunteers Study), which is not on this map. Cited by 98 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vaginal Metabolome Healthy Volunteers Study
Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it, 190 citations in OpenAlex.
- Age-related uterine changes and its association with poor reproductive outcomes: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Tissue-specific microbiota dictates the competitive dynamics ofThe veterinary quarterly · 2026Article
- Association Between Vaginal Microbiota and Female Infertility: A Systematic Review and Meta-Analysis.Microorganisms · 2026Review
- Review
- Comparison of pregnancy outcomes and vaginal microbiota in women with endometriosis undergoing frozen embryo transfer using letrozole combined with HMG versus hormone replacement therapy with GnRH-a pretreatment.Journal of biomedical research · 2026Article
- Assessing the female urogenital-rectal axis microbiome: focus on endometriosis and recurrent implantation failure.Reproductive biology and endocrinology : RB&E · 2026Article
- Uterine microbiome signatures associated with endometriosis.BMC biology · 2026Article
- Exploring the Association Between Gut Microbiota and Infertility in Women with Multiple Implantation Failures: An Exploratory Study.Microorganisms · 2026Article
- The role of the microbiome in uterine cancer: insights into tumorigenesis, therapeutic implications, and clinical prospects.Journal of the Egyptian National Cancer Institute · 2026Review
- Article
- Presence and Dominance ofDiseases (Basel, Switzerland) · 2026Article
- Bacterial Extracellular Vesicles: New Hype or Hope to Explain Reproductive Host-Microbiota Interactions.Journal of extracellular vesicles · 2026Review
- Endometrial microbiota-dimethylglycine-Treg cell axis affects endometrial receptivity in recurrent implantation failure.Science China. Life sciences · 2026Article
- LPS-induced endometrial cell-derived exosomes suppress probiotic Lactobacillus growth.Scientific reports · 2026Article
- Review
- Structural and functional characteristics of faecal, vaginal and colostrum microbiota in high-yielding sows.Microbial genomics · 2026Article
- Advances in the Role of Endometrial Microbiota Alterations in the Pathogenesis of Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Astragaloside IV AlleviatesAntioxidants (Basel, Switzerland) · 2026Article
- Systems-level restoration of vaginal and gut microbiota by Lactobacillus helveticus 20838 alleviates Gardnerella vaginalis-induced dysbiosis.The ISME journal · 2026Article
- Dual Role of the Endometrial Microbiome-Immune Axis: From Endometrial Homeostasis to Reproductive Disorders.International journal of women's health · 2026Review
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vaginal and uterine microbiota play important roles in the health of the female reproductive system. However, the interactions among the microbes in these two niches and their effects on uterine health remain unclear. Here we profile the vaginal and uterine microbial samples of 145 women, and combine with deep mining of public data and animal experiments to characterize the microbial translocation in the female reproductive tract and its role in modulating uterine health. Synchronous variation and increasing convergence of the uterine and vaginal microbiome with advancing age are shown. We also find that transplanting certain strains of vaginal bacteria into the vagina of rats induces or reduces endometritis-like symptoms, and verify the damaging or protective effects of certain vaginal bacteria on endometrium. This study clarifies the interdependent relationship of vaginal bacterial translocation with uterine microecology and endometrial health, which will undoubtedly increase our understanding of female reproductive health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.