Evidence map›Paper›PMID 34234015›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Clock proteins regulate spatiotemporal organization of clock genes to control circadian rhythms.

Yangbo Xiao, Ye Yuan, Mariana Jimenez, Neeraj Soni, Swathi Yadlapalli

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Hsp70s regulate circadian rhythm by interacting with PERIOD.Cell communication and signaling : CCS · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. An intron-based timer for circadian rhythms.bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Day-night gene expression reveals circadian geneProceedings. Biological sciences · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Regulation of circadian rhythms by clock protein nuclear bodies.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Mammalian circadian clock proteins form dynamic interacting microbodies distinct from phase separation.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yangbo XiaoDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Ye YuanDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-9641-9102
Mariana JimenezDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-8475-5579
Neeraj SoniDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-4191-6723
Swathi YadlapalliDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109; swathi@umich.edu.
University of Michigan · US

Funding

Spatiotemporal mechanisms controlling circadian rhythmsR35GM133737 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Swathi Yadlapalli · 2019 to 2026
$3.4M
NIGMS NIH HHS R35 GM133737
6 · The paper itself

Abstract

Circadian clocks regulate ∼24-h oscillations in gene expression, behavior, and physiology. While the genetic and molecular mechanisms of circadian rhythms are well characterized, what remains poorly understood are the intracellular dynamics of circadian clock components and how they affect circadian rhythms. Here, we elucidate how spatiotemporal organization and dynamics of core clock proteins and genes affect circadian rhythms in

Indexed as

Gene Expression RegulationAnimalsCell NucleusCircadian ClocksCircadian RhythmCLOCK ProteinsDrosophila melanogasterDrosophila ProteinsLamin B ReceptorPeriod Circadian ProteinsReceptors, Cytoplasmic and NuclearTime FactorsTime-Lapse ImagingClk protein, DrosophilaCLOCK ProteinsDrosophila ProteinsLamin B ReceptorPeriod Circadian ProteinsPER protein, DrosophilaReceptors, Cytoplasmic and Nuclearcircadian rhythmslive imagingnuclear organization

Identifiers

PMID34234015
PMCPMC8285898
OpenAlexW3177736887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.