Evidence map›Paper›PMID 34233969›Full record

ArticleBMJ open2021

Secondary analyses to test the impact on inequalities and uptake of the schools-based human papillomavirus (HPV) vaccination programme by stage of implementation of a new consent policy in the south-west of England.

Harriet Fisher, Karen Evans, Rosy Reynolds, Julie Yates, Marion Roderick, Jo Ferrie, John Macleod, Matthew Hickman, Suzanne Audrey

Abstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Harriet FisherBristol Medical School, University of Bristol, Bristol, UK Harriet.Fisher@bristol.ac.uk.ORCID 0000-0002-5639-0955
Karen EvansSirona Care and Health CIC, Kingswood, South Gloucestershire, UK.
Rosy ReynoldsBristol Medical School, University of Bristol, Bristol, UK.
Julie YatesScreening and Immunisations South West, Public Health England, London, UK.
Marion RoderickDepartment of Paediatric Immunology & Infectious Diseases, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, Bristol, UK.
Jo FerrieScreening and Immunisations South West, Public Health England, London, UK.
John MacleodBristol Medical School, University of Bristol, Bristol, UK.
Matthew HickmanBristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0001-9864-459X
Suzanne AudreyBristol Medical School, University of Bristol, Bristol, UK.

Funding

Department of Health PB-PG-0416-20013Medical Research Council MR/T027150/1Wellcome Trust
6 · The paper itself

Abstract

objectivesTo test the impact on inequalities and uptake of the schools-based human papillomavirus (HPV) vaccination programme by stage of implementation of a new policy providing additional opportunities to consent.

settingTwo local authorities in the south-west of England.

participantsYoung women (n=7129) routinely eligible for HPV vaccination aged 12-13 years during the intervention period (2017/2018 to 2018/2019 programme years).

interventionsLocal policy change that included additional opportunities to provide consent (parental verbal consent and adolescent self-consent). OUTCOMES: Secondary analyses of cross-sectional intervention data were undertaken to examine uptake by: (1) receipt of parental written consent forms and; (2) percentage of unvaccinated young women by stage of implementation.

resultsDuring the intervention period, 6341 (89.0%) eligible young women initiated the HPV vaccination series. Parental written consent forms were less likely to be returned where young women attended alternative education provider settings (p<0.001), belonged to non-white British ethnic groups (p<0.01) or more deprived quintiles (p<0.001). Implementation of parental verbal consent and adolescent self-consent reduced the percentage of unvaccinated young women from 21.3% to 16.5% (risk difference: 4.8%). The effect was greater for young women belonging to the most deprived compared with the least deprived quintile (risk difference: 7.4% vs 2.3%, p<0.001), and for young women classified as Unknown ethnic category compared with white British young women (6.7% vs 4.2%, p<0.001). No difference was found for non-white British young women (5.4%, p<0.21).

conclusionsLocal policy change to consent procedures that allowed parents to consent verbally and adolescents to self-consent overcame some of the barriers to vaccination of young women belonging to families less likely to respond to paper-based methods of gaining consent and at greater risk of developing cervical cancer. TRIAL REGISTRATION NUMBER: 49 086 105.

Indexed as

AlphapapillomavirusPapillomavirus InfectionsPapillomavirus VaccinesUterine Cervical NeoplasmsAdolescentCross-Sectional StudiesEnglandFemaleHumansParental ConsentPatient Acceptance of Health CarePolicySchoolsVaccinationPapillomavirus Vaccinescommunity child healthinfectious diseasespublic health

Identifiers

PMID34233969
PMCPMC8264897

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.