ArticleScience translational medicine2021
Pan-caspase inhibition as a potential host-directed immunotherapy against MRSA and other bacterial skin infections.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Emerging host-directed strategies for overcoming drug resistance and immune evasion in Staphylococcus aureus infections.Journal of advanced research · 2026Review
- Article
- Targeting alveolar epithelial cells with lipid micelle-encapsulated necroptosis inhibitors to alleviate acute lung injury.Communications biology · 2025Article
- Mechanistic insights into the multitarget synergistic efficacy of farrerol and β-lactam antibiotics in combating methicillin-resistantAntimicrobial agents and chemotherapy · 2025Article
- Neutrophil heterogeneity and plasticity: unveiling the multifaceted roles in health and disease.MedComm · 2025Review
- Effects of the pan-caspase inhibitor Q-VD-OPh on human neutrophil lifespan and function.PloS one · 2025Article
- The intricate pathogenicity of Group AVirulence · 2024Review
- Crosstalk of pyroptosis and cytokine in the tumor microenvironment: from mechanisms to clinical implication.Molecular cancer · 2024Review
- Triggering Toll-Like Receptor 5 Signaling During Pneumococcal Superinfection Prevents the Selection of Antibiotic Resistance.The Journal of infectious diseases · 2024Article
- Staphyloccocus aureus biofilm, in absence of planktonic bacteria, produces factors that activate counterbalancing inflammatory and immune-suppressive genes in human monocytes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Immune Responses to Methicillin-ResistantVaccines · 2024Review
- Targeting host deoxycytidine kinase mitigateseLife · 2024Article
- From Host Defense to Metabolic Signatures: Unveiling the Role of γδ T Cells in Bacterial Infections.Biomolecules · 2024Review
- Sarin-Induced Neuroinflammation in Mouse Brain Is Attenuated by the Caspase Inhibitor Q-VD-OPh.The Journal of pharmacology and experimental therapeutics · 2024Article
- Identification of kinase modulators as host-directed therapeutics against intracellular methicillin-resistantFrontiers in cellular and infection microbiology · 2024Article
- Single-Cell Analysis of CX3CR1+ Cells Reveals a Pathogenic Role for BIRC5+ Myeloid Proliferating Cells Driven by Staphylococcus aureus Leukotoxins.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation.Cell reports. Medicine · 2023Article
- Neutrophil-intrinsic TNF receptor signaling orchestrates host defense againstScience advances · 2023Article
- Inflammasome activation by Gram-positive bacteria: Mechanisms of activation and regulation.Frontiers in immunology · 2023Review
- PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 1 institution in 1 country.
Martin P AlphonseDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0003-3447-1284
Jessica H RubensDivison of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21210, USA.ORCID 0000-0001-9198-9149
Roger V OrtinesDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0001-9650-3072
Nicholas A OrlandoDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0002-3999-4845
Aman M PatelDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0003-0794-041X
Dustin DikemanDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Yu WangDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0002-4153-7360
Ivan VuongDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0002-3946-4772
Daniel P JoyceDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Jeffrey ZhangDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Mohammed MumtazDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0002-7333-9756
Haiyun LiuDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0002-0485-2695
Qi LiuDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Christine YounDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0002-0022-2848
Garrett J PatrickDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Advaitaa RavipatiDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0001-5557-7817
Robert J MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0002-7662-6136
Nathan K ArcherDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. narcher2@jhmi.edu lloydmiller@jhmi.edu.ORCID 0000-0002-8212-8985
Lloyd S MillerDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. narcher2@jhmi.edu lloydmiller@jhmi.edu.ORCID 0000-0002-8332-2210
Johns Hopkins University · US
Funding
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4MResearch Training in Pediatric Infectious DiseasesT32AI052071 · NIAID · JOHNS HOPKINS UNIVERSITY · PI AARON M MILSTONE · 2002 to 2026
$5.2MIL-36 responses in Staphylococcus aureus driven skin inflammationR01AR073665 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2018 to 2022
$1.8MSTAT3-mediated immunity to Staphylococcus aureus in skinR01AR069502 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2016 to 2020
$1.8MNIAID NIH HHS T32 AI052071NIAMS NIH HHS R01 AR069502NIAMS NIH HHS R01 AR073665NIGMS NIH HHS T32 GM136577
Abstract
PubMed holds no abstract for this paper.
Indexed as
CaspasesMethicillin-Resistant Staphylococcus aureusAnimalsCaspase 1Caspase InhibitorsImmunotherapyInflammasomesInterleukin-1betaMiceTumor Necrosis Factor InhibitorsCaspase 1Caspase InhibitorsCaspasesInflammasomesInterleukin-1betaTumor Necrosis Factor Inhibitors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.