Evidence map›Paper›PMID 34233953›Full record

ArticleScience translational medicine2021

A recombinant commensal bacteria elicits heterologous antigen-specific immune responses during pharyngeal carriage.

Jay R Laver, Diane Gbesemete, Adam P Dale, Zoe C Pounce, Carl N Webb, Eleanor F Roche, Jonathan M Guy, Graham Berreen, Konstantinos Belogiannis, Alison R Hill and 11 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Jay R LaverFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK. j.r.laver@soton.ac.uk.ORCID 0000-0003-3314-5989
Diane GbesemeteFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Adam P DaleFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0001-8163-7481
Zoe C PounceFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Carl N WebbFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0001-6401-4397
Eleanor F RocheFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Jonathan M GuyFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Graham BerreenFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
Konstantinos BelogiannisFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0001-6505-6476
Alison R HillFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0001-5397-873X
Muktar M IbrahimFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0002-2027-3095
Muhammad AhmedFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0003-3234-2788
David W ClearyFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0003-4533-0700
Anish K PandeyFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0002-4149-8154
Holly E HumphriesPublic Health England, Porton Down, Salisbury SP4 0JG, UK.ORCID 0000-0003-2576-8502
Lauren AllenPublic Health England, Porton Down, Salisbury SP4 0JG, UK.ORCID 0000-0003-1846-8181
Hans de GraafFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0001-8055-8749
Martin C MaidenDepartment of Zoology, University of Oxford, Oxford OX1 3SZ, UK.ORCID 0000-0001-6321-5138
Saul N FaustFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0003-3410-7642
Andrew R GorringePublic Health England, Porton Down, Salisbury SP4 0JG, UK.ORCID 0000-0003-2193-7954
Robert C ReadFaculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.ORCID 0000-0002-4297-6728
NIHR Southampton Biomedical Research Centre · GBUniversity of Southampton · GBPublic Health England · GBUniversity of Oxford · GB

Funding

Medical Research Council MR/N013204/1Medical Research Council MR/N026993/1Wellcome Trust 203581Wellcome Trust 203581/Z/16/Z
6 · The paper itself

Abstract

The human nasopharynx contains a stable microbial ecosystem of commensal and potentially pathogenic bacteria, which can elicit protective primary and secondary immune responses. Experimental intranasal infection of human adults with the commensal

Indexed as

Meningococcal VaccinesNeisseria lactamicaAdultAntibodies, BacterialAntigens, HeterophileEcosystemHumansImmunologic MemoryAntibodies, BacterialAntigens, HeterophileMeningococcal Vaccines

Identifiers

PMID34233953
PMCPMC7615050
OpenAlexW3171788587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.