ArticleScience translational medicine2021
Genome-encoded cytoplasmic double-stranded RNAs, found in
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05189106 (Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis), which is not on this map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT05189106 phase1 / phase2completednot on this mapstarted 2022, after this paper: background citation
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Proof of Concept Trial Including Asymptomatic Individuals Using Baricitinib
Who cites it
38 citing papers in PubMed, 52 citations in OpenAlex.
- LINE-1 Retrotransposons and Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2026Review
- Microglial Dysfunction Induced by C9ORF72 Dipeptide Repeat Proteins: Biomarker and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Polypharmacology is an enduring and nearly universal property of kinase inhibitors.bioRxiv : the preprint server for biology · 2026Article
- RNA-binding proteins: a comprehensive review of multifaceted regulatory mechanisms in neuroinflammation and implications in the pathogenesis of neurological disorders.Journal of neuroinflammation · 2026Review
- TYK2 mediates neuroinflammation in Alzheimer's disease brains with TDP-43 pathology.Nature communications · 2026Article
- Tui Na Acupressure Modulates Treg Immunosuppression via FoxP3/mTORC1 Signalling in ALS Mice.Immunology · 2026Article
- RIG-I Mediated Neuron-Specific IFN Type 1 Signaling in FUS-ALS Induces Neurodegeneration and Offers New Biomarker-Driven Individualized Treatment Options for (FUS-)ALS.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy.Nature neuroscience · 2026Article
- Review of Promising Off-Label Use of Deucravacitinib.International journal of molecular sciences · 2025Review
- Mitochondrial Dysfunction is a Crucial Immune Checkpoint for Neuroinflammation and Neurodegeneration: mtDAMPs in Focus.Molecular neurobiology · 2025Review
- CNS disease associated with enhanced type I interferon signalling.The Lancet. Neurology · 2024Review
- Microbiome and micronutrient in ALS: From novel mechanisms to new treatments.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Pharmacotherapies for the Treatment of Progressive Supranuclear Palsy: A Narrative Review.Neurology and therapy · 2024Review
- TYK2 as a novel therapeutic target in Alzheimer's Disease with TDP-43 inclusions.bioRxiv : the preprint server for biology · 2024Article
- Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia.Acta neuropathologica · 2024Article
- Early-stage idiopathic Parkinson's disease is associated with reduced circular RNA expression.NPJ Parkinson's disease · 2024Article
- The role of interferon signaling in neurodegeneration and neuropsychiatric disorders.Frontiers in psychiatry · 2024Review
- A comprehensive review of electrophysiological techniques in amyotrophic lateral sclerosis research.Frontiers in cellular neuroscience · 2024Review
- The Sixth Sense: Self-nucleic acid sensing in the brain.Advances in immunology · 2024Review
- Long 3'UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation.Science immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 1 country.
Steven RodriguezDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-2708-5791
Asli SahinDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-4706-3071
Benjamin R SchrankDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0001-8138-4250
Hawra Al-LawatiDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0001-5228-1025
Isabel CostantinoDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0001-8807-2305
Eric BenzDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
Darian FardDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-4413-1833
Alefiya D AlbersDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0003-2660-6927
Luxiang CaoDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.
Alexis C GomezDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0003-3522-623X
Kyle EvansDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-6246-9520
Elena RattiDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-9321-7908
Merit CudkowiczDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-7075-1681
Matthew P FroschDepartment of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0002-3940-9861
Michael TalkowskiDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0003-2889-0992
Peter K SorgerLaboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-3364-1838
Bradley T HymanDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-7959-9401
Mark W AlbersDepartment of Neurology, Massachusetts General Hospital, Boston, MA 02129, USA. albers.mark@mgh.harvard.edu.ORCID 0000-0001-7855-3455
Massachusetts General Hospital · USHarvard University · USEndicott College · US
Funding
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1MResearch Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Sudeshna Das · 2019 to 2026
$36.5MTRANSLATIONAL PHARMACOLOGY COREP50GM107618 · NIGMS · HARVARD MEDICAL SCHOOL · PI MALISZEWSKI, LAURA ELIZABETH · 2014 to 2018
$10.8MHarnessing Diverse Bioinformatic Approaches To Repurpose Drugs For Alzheimers Disease And Related DementiasR01AG058063 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI MARK W ALBERS, PETER Karl SORGER · 2018 to 2026
$7.8MThe Olfactory Neural Circuit as a systems Level Model of Neurodegenerative DiseasDP2OD006662 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI ALBERS, MARK W · 2009 to 2009
$2.7MHarnessing Diverse BioInformatic Approaches to Repurpose Drugs for Alzheimer's DiseaseR56AG058063 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI ALBERS, MARK W, SORGER, PETER KARL · 2017 to 2017
$835kPropagation of Neurodegeneration by Innate Immune Pattern Recognition Receptors In VivoR21NS094861 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ALBERS, MARK W · 2015 to 2016
$457kNIA NIH HHS P30 AG062421NIA NIH HHS P50 AG005134NIA NIH HHS R01 AG058063NIA NIH HHS R56 AG058063NIGMS NIH HHS P50 GM107618NIH HHS DP2 OD006662NINDS NIH HHS R21 NS094861
Abstract
Triggers of innate immune signaling in the CNS of patients with amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD) remain elusive. We report the presence of cytoplasmic double-stranded RNA (cdsRNA), an established trigger of innate immunity, in ALS-FTD brains carrying
Indexed as
Amyotrophic Lateral SclerosisC9orf72 ProteinFrontotemporal DementiaAnimalsBrainDNA Repeat ExpansionHumansMiceRNA, Double-StrandedC9orf72 ProteinC9orf72 protein, humanRNA, Double-Stranded
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT05189106ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.