ArticleDiabetes2021
Profile of Podocyte Translatome During Development of Type 2 and Type 1 Diabetic Nephropathy Using Podocyte-Specific TRAP mRNA RNA-seq.
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Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Claudin 5 Across the Vascular Landscape: From Blood-Tissue Barrier Regulation to Disease Mechanisms.Cells · 2025Review
- Cross Talk Between Macrophages and Podocytes in Diabetic Nephropathy: Potential Mechanisms and Novel Therapeutics.Mediators of inflammation · 2025Review
- Tribbles pseudokinase 3 promoted renal fibrosis by regulating the expression of DNA damage-inducible transcript 3 in diabetic nephropathy.Biomolecules & biomedicine · 2024Article
- LRG1 loss effectively restrains glomerular TGF-β signaling to attenuate diabetic kidney disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets.International journal of molecular sciences · 2024Review
- Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury.Kidney international · 2024Article
- Autoimmune CD8+ T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirection.Frontiers in endocrinology · 2024Review
- Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases.The Journal of clinical investigation · 2023Article
- The crosstalk between glomerular endothelial cells and podocytes controls their responses to metabolic stimuli in diabetic nephropathy.Scientific reports · 2023Article
- Research progress on multiple cell death pathways of podocytes in diabetic kidney disease.Molecular medicine (Cambridge, Mass.) · 2023Review
- Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
- Clopidogrel delays and can reverse diabetic nephropathy pathogenesis in type 2 diabeticWorld journal of diabetes · 2022Article
- Triptolide inhibits oxidative stress and inflammation via the microRNA-155-5p/brain-derived neurotrophic factor to reduce podocyte injury in mice with diabetic nephropathy.Bioengineered · 2022Article
Corrections and comments
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Authors and funding
18 authors at 1 institution in 1 country.
Yinqiu WangDivision of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN.
Aolei NiuDivision of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN.
Yu PanDivision of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN.
Shirong CaoDivision of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN.
Andrew S TerkerDivision of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN.
Suwan WangDivision of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN.
Xiaofeng FanDivision of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN.
Cynthia L TothDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Marisol A Ramirez SolanoDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Danielle L MichellDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Danielle ContrerasDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Ryan M AllenDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Wanying ZhuDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Quanhu ShengDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Agnes B FogoDivision of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN.
Kasey C VickersDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Ming-Zhi ZhangDivision of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN ray.harris@vumc.org ming-zhi.zhang@vumc.org.
Raymond C HarrisDivision of Nephrology and Hypertension, Vanderbilt University School of Medicine, Nashville, TN ray.harris@vumc.org ming-zhi.zhang@vumc.org.ORCID 0000-0001-8025-0883
Vanderbilt University · US
Funding
Non-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LINTON, MACRAE F · 2014 to 2025
$24.7MRoles for Supermeres in CRC ProgressionP01CA229123 · NCI · VANDERBILT UNIVERSITY · PI Alissa M Weaver · 2020 to 2026
$12.9MThe Role of the EGF Receptor in Acute and Chronic Renal InjuryR01DK051265 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 1997 to 2026
$10.1MThe role of the innate immune cell cyclooxygenase/prostaglandin system in blood pressureregulationR01DK062794 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2003 to 2026
$9.4MThe Role of renal macrophages in recovery from renal injuryR01DK095785 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RAYMOND C. HARRIS, Mingzhi Zhang · 2013 to 2026
$6.7MNovel Integrated Analyses of Human Diabetic NephropathyR24DK103067 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CAPRIOLI, RICHARD M, DENNY, JOSHUA C. · 2014 to 2018
$6.5MVanderbilt O'Brien Kidney Center - Core D - Clinical and Translational CoreP30DK114809 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DE CAESTECKER, MARK P. · 2017 to 2021
$5.9MVANDERBILT NEPHROLOGY TRAINING PROGRAMT32DK007569 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRIS, RAYMOND C., IKIZLER, TALAT ALP · 1988 to 2024
$5.8MIn Situ Albumin Binding siRNAs for Triple Negative Breast Cancer Tumor Penetration and Molecularly Targeted TherapyR01CA260958 · NCI · VANDERBILT UNIVERSITY · PI COOK, REBECCA SARA, DUVALL, CRAIG LEWIS · 2021 to 2025
$3.0MBLRD VA I01 BX000320NCI NIH HHS P01 CA229123NCI NIH HHS R01 CA260958NHLBI NIH HHS P01 HL116263NIDDK NIH HHS P30 DK114809NIDDK NIH HHS R01 DK051265NIDDK NIH HHS R01 DK062794NIDDK NIH HHS R01 DK095785NIDDK NIH HHS R24 DK103067NIDDK NIH HHS T32 DK007569
Abstract
Podocyte injury is important in development of diabetic nephropathy (DN). Although several studies have reported single-cell-based RNA sequencing (RNA-seq) of podocytes in type 1 DN (T1DN), the podocyte translating mRNA profile in type 2 DN (T2DN) has not previously been compared with that of T1DN. We analyzed the podocyte translatome in T2DN in podocin-Cre; Rosa26
Indexed as
AnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NephropathiesGene Expression ProfilingMaleMiceMice, Inbred C57BLMice, KnockoutOrgan SpecificityPodocytesProtein BiosynthesisProteomeRNA, MessengerRNA-SeqProteomeRNA, MessengerStreptozocin
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What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.