Evidence map›Paper›PMID 34233914›Full record

ArticleOpen heart2021

Early reduction of left atrial function predicts adverse clinical outcomes in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement.

Jolanda Sabatino, Salvatore De Rosa, Isabella Leo, Antonio Strangio, Sabrina La Bella, Sabato Sorrentino, Annalisa Mongiardo, Carmen Spaccarotella, Alberto Polimeni, Ciro Indolfi

Abstract read
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In one paragraph

Article in Open heart, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Hypertension in aortic coarctation.Frontiers in cardiovascular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jolanda SabatinoDepartment of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Salvatore De RosaDepartment of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy saderosa@unicz.it indolfi@unicz.it.ORCID 0000-0001-5388-942X
Isabella LeoDepartment of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Antonio StrangioDepartment of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Sabrina La BellaDepartment of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Sabato SorrentinoDepartment of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Annalisa MongiardoDepartment of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Carmen SpaccarotellaDepartment of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Alberto PolimeniDepartment of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Ciro IndolfiDepartment of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy saderosa@unicz.it indolfi@unicz.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate the changes in left atrial strain (LAS) after correction of severe aortic stenosis (AS) with transcatheter aortic valve replacement (TAVR) and assess its prognostic impact. METHODS AND

resultsOne hundred consecutive patients with severe symptomatic AS who underwent TAVR at the Magna Graecia University of Catanzaro underwent echocardiographic examination including assessment of LAS before and after TAVR. Independent investigators collected outcome data and information. The primary study outcome was the difference in ΔLAS (postTAVR-preTAVR) between patients those met the main clinical endpoint (a composite of cardiovascular mortality and heart failure hospitalisation) and those not meeting the endpoint.During a median follow-up of 31 months, 35 patients (35%) met the combined clinical endpoint. The difference between LAS post-TAVR and LAS pre-TAVR (ΔLAS) was significantly larger in patients who met the combined endpoint (HR=0.76 (0.67-0.86); p<0.001). Multivariate logistic regression analysis including ΔLAS, EuroSCORE II and left ventricular ejection fraction showed that ΔLAS (HR=0.80, p<0.001) was the only independent predictor of the combined clinical endpoint. Finally, a Kaplan-Maier analysis showed that patients with a ΔLAS above its median value had a significantly better event-free survival compared with those below the median (p<0.001).

conclusionsA lower reduction in ΔLAS after TAVR was an independent predictor of the primary composite outcome of cardiovascular death and hospitalisation for heart failure.

Indexed as

Early DiagnosisAged, 80 and overAortic ValveAortic Valve StenosisAtrial Function, LeftDisease ProgressionEchocardiography, DopplerFemaleFollow-Up StudiesHeart AtriaHeart FailureHumansIncidenceItalyMalePrognosisechocardiographyheart failuretranscatheter aortic valve replacement

Identifiers

PMID34233914
PMCPMC8264907

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.