Evidence map›Paper›PMID 34233878›Full record

ArticleScience advances2021

Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4

Amit Jairaman, Shivashankar Othy, Joseph L Dynes, Andriy V Yeromin, Angel Zavala, Milton L Greenberg, Jamison L Nourse, Jesse R Holt, Stuart M Cahalan, Francesco Marangoni and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 104 citations in OpenAlex.

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  9. NaFrontiers in chemistry · 2026
    Article
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  12. Mechanobiology of Myelin Generation/Regeneration in Health and Disease.Results and problems in cell differentiation · 2026
    Review
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Amit JairamanDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.ORCID 0000-0002-5206-700X
Shivashankar OthyDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.ORCID 0000-0001-6832-5547
Joseph L DynesDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.
Andriy V YerominDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.
Angel ZavalaDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.
Milton L GreenbergDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.ORCID 0000-0001-9451-2311
Jamison L NourseDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.
Jesse R HoltDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.ORCID 0000-0001-8136-6394
Stuart M CahalanHoward Hughes Medical Institute, Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.
Francesco MarangoniDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.ORCID 0000-0002-2490-849X
Ian ParkerDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.ORCID 0000-0001-8734-4081
Medha M PathakDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA.
Michael D CahalanDepartment of Physiology and Biophysics, University of California, Irvine, CA 92697-4561, USA. mcahalan@uci.edu.ORCID 0000-0002-4987-2526
University of California, Irvine · USScripps Research Institute · US

Funding

Molecular Mechanisms of lon Channels in T LymphocytesR01NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 1985 to 2022
$7.0M
Elementary Events of Intracellular Calcium SignalingR37GM048071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PARKER, IAN · 2011 to 2020
$5.3M
SPATIAL AND TEMPORAL ASPECTS OF INSP3 SIGNALLINGR01GM048071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PARKER, IAN · 1992 to 2010
$3.9M
Molecular Mechanisms of Ion Channels in T LymphocytesR37NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2006 to 2012
$3.3M
Building the brain: How mechanical forces shape human neural developmentDP2AT010376 · NCCIH · UNIVERSITY OF CALIFORNIA-IRVINE · PI PATHAK, MEDHA M · 2018 to 2020
$2.9M
Cellular and Molecular Mechanisms of Regulatory T Cells in EAER01AI121945 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2016 to 2020
$2.5M
Piezo1 in neural stem cell mechano-regulationR01NS109810 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PATHAK, MEDHA M · 2018 to 2022
$2.2M
Molecular Mechanisms of lon Channels in T LymphocytesR56NS014609 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2018 to 2018
$514k
Mechanisms of Macrophage Functional Switch during Skin RepairR21AR072849 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARANGONI, FRANCESCO · 2019 to 2020
$379k
Cellular and Molecular Mechanisms of Regulatory T Cells in EAER56AI121945 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAHALAN, MICHAEL D · 2016 to 2016
$103k
Howard Hughes Medical InstituteNCCIH NIH HHS DP2 AT010376NIAID NIH HHS R01 AI121945NIAID NIH HHS R56 AI121945NIAMS NIH HHS R21 AR072849NIGMS NIH HHS R01 GM048071NIGMS NIH HHS R37 GM048071NINDS NIH HHS R01 NS014609NINDS NIH HHS R01 NS109810NINDS NIH HHS R37 NS014609NINDS NIH HHS R56 NS014609
6 · The paper itself

Abstract

T lymphocytes encounter complex mechanical cues during an immune response. The mechanosensitive ion channel, Piezo1, drives inflammatory responses to bacterial infections, wound healing, and cancer; however, its role in helper T cell function remains unclear. In an animal model for multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), we found that mice with genetic deletion of Piezo1 in T cells showed diminished disease severity. Unexpectedly, Piezo1 was not essential for lymph node homing, interstitial motility, Ca

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisAnimalsCell DifferentiationIon ChannelsLymphocyte ActivationMiceMice, Inbred C57BLTh1 CellsT-Lymphocytes, RegulatoryIon ChannelsPiezo1 protein, mouse

Identifiers

PMID34233878
PMCPMC8262815
OpenAlexW3177851364

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.